Citation: Jie Li, Zhongshi Wang, Han Han, Zhonghua Xu, Shasha Li, Ying Zhu, Yuejian Chen, Liang Ge, Yuan Zhang. Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery[J]. Chinese Chemical Letters, ;2022, 33(4): 1936-1940. doi: 10.1016/j.cclet.2021.10.058 shu

Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery

Jie Li ^{a, 1} ,
Zhongshi Wang ^{a, b, 1} ,
Han Han ^b ,
Zhonghua Xu ^a ,
Shasha Li ^c ,
Ying Zhu ^b ,
Yuejian Chen ^d ,
Liang Ge ^{b, c} ,
Yuan Zhang ^{a, *,}

a.
Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing 400038, China
b.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
c.
School of Pharmacy, Xinjiang Medical University, Urumqi 830054, China
d.
Nanjing aifarui Pharmaceutical Technology Co., Ltd., Nanjing 210009, China

zhangyuan@tmmu.edu.cn

Received Date: 29 July 2021
Revised Date: 16 October 2021
Accepted Date: 19 October 2021
Available Online: 29 October 2021

Figures(5)

Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin (DOX) using a pH-responsive ionic-complementary octapeptide FOE. This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at pH 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence.
- Peptide hydrogel,
- pH Sensitivity,
- Antitumor,
- Drug delivery,
- Targeted therapy
1. [1]
  J.A. Kemp, M.S. Shim, C.Y. Heo, Y.J. Kwon, Adv. Drug Deliv. Rev. 98 (2016) 3-18. doi: 10.1016/j.addr.2015.10.019
2. [2]
  C. Wu, J. Liu, X. Tang, et al., Chem. Commun. 55 (2019) 14852-14855. doi: 10.1039/C9CC06204A
3. [3]
  Y. Zhu, L. Wang, Y. Li, et al., Biomater. Sci. 8 (2020) 5415-5426. doi: 10.1039/D0BM01004A
4. [4]
  J. Huang, X. You, P. Xin, et al., Chin. Chem. Lett. 32 (2021) 1737-1742. doi: 10.1016/j.cclet.2020.12.006
5. [5]
  M. Cagel, E. Grotz, E. Bernabeu, M.A. Moretton, D.A. Chiappetta, Drug Discov. Today 22 (2017) 270-281. doi: 10.1016/j.drudis.2016.11.005
6. [6]
  N. Oliva, J. Conde, K. Wang, N. Artzi, Acc. Chem. Res. 50 (2017) 669-679. doi: 10.1021/acs.accounts.6b00536
7. [7]
  J. Xie, Y. Lu, B. Yu, J. Wu, J. Liu, Chin. Chem. Lett. 31 (2020) 1173-1177. doi: 10.1016/j.cclet.2019.10.030
8. [8]
  A.S. Hoffman, Adv. Drug Deliv. Rev. 54 (2002) 3-12. doi: 10.1016/S0169-409X(01)00239-3
9. [9]
  Q. Huang, Y. Zou, M.C. Arno, et al., Chem. Soc. Rev. 46 (2017) 6255-6275. doi: 10.1039/C6CS00052E
10. [10]
  Y. Wen, J.H. Collier, Curr. Opin. Immunol. 35 (2015) 73-79. doi: 10.1016/j.coi.2015.06.007
11. [11]
  M. Norouzi, B. Nazari, D.W. Miller, Drug Discov. Today 21 (2016) 1835-1849. doi: 10.1016/j.drudis.2016.07.006
12. [12]
  T. Thambi, Y. Li, D.S. Lee, J. Control. Release 267 (2017) 57-66. doi: 10.1016/j.jconrel.2017.08.006
13. [13]
  A.M. Jonker, D.W.P.M. Löwik, J.C.M. van Hest, Chem. Mater. 24 (2012) 759-773. doi: 10.1021/cm202640w
14. [14]
  J. Wang, K. Liu, R. Xing, X. Yan, Chem. Soc. Rev. 45 (2016) 5589-5604. doi: 10.1039/C6CS00176A
15. [15]
  X.R. You, L.Y. Wang, L. Wang, J. Wu, Adv. Funct. Mater. 31 (2021) 2100805. doi: 10.1002/adfm.202100805
16. [16]
  A. Mujeeb, A.F. Miller, A. Saiani, J.E. Gough, Acta Biomater. 9 (2013) 4609-4617. doi: 10.1016/j.actbio.2012.08.044
17. [17]
  S. Eskandari, T. Guerin, I. Toth, R.J. Stephenson, Adv. Drug Deliv. Rev. 110-111 (2017) 169-187.
18. [18]
  M.J. Sis, M.J. Webber, Trends Pharmacol. Sci. 40 (2019) 747-762. doi: 10.1016/j.tips.2019.08.003
19. [19]
  F. Gelain, Z. Luo, S. Zhang, Chem. Rev. 120 (2020) 13434-13460. doi: 10.1021/acs.chemrev.0c00690
20. [20]
  M.J. Webber, C.J. Newcomb, R. Bitton, S.I. Stupp, Soft Matter 7 (2011) 9665-9672. doi: 10.1039/c1sm05610g
21. [21]
  P. Liang, J. Zheng, S. Dai, et al., J. Control. Release 260 (2017) 22-31. doi: 10.1016/j.jconrel.2017.05.018
22. [22]
  Z.Y. Sun, C.J. Song, C. Wang, Y.Q. Hu, J.H. Wu, Mol. Pharm. 17 (2020) 373-391.
23. [23]
  N.K. Singh, D.S. Lee, J. Control. Release 193 (2014) 214-227. doi: 10.1016/j.jconrel.2014.04.056
24. [24]
  H. Zhang, J. Park, Y. Jiang, K.A. Woodrow, Acta Biomater. 55 (2017) 183-193. doi: 10.1016/j.actbio.2017.03.041
25. [25]
  M.R. Caplan, P.N. Moore, S.G. Zhang, R.D. Kamm, D.A. Lauffenburger, Biomacromolecules 1 (2000) 627-631. doi: 10.1021/bm005586w
26. [26]
  Z. Yang, H. Xu, X. Zhao, Adv. Sci. 7 (2020) 1903718. doi: 10.1002/advs.201903718
27. [27]
  G. Fichman, E. Gazit, Acta Biomater 10 (2014) 1671-1682. doi: 10.1016/j.actbio.2013.08.013
28. [28]
  L. Mei, S. He, Z. Liu, K. Xu, W. Zhong, Chem. Commun. 55 (2019) 4411-4414. doi: 10.1039/C9CC00590K
29. [29]
  X.D. Xu, C.S. Chen, B. Lu, et al., J. Phys. Chem. B 114 (2010) 2365-2372.
30. [30]
  E. Beniash, J.D. Hartgerink, H. Storrie, J.C. Stendahl, S.I. Stupp, Acta Biomater. 1 (2005) 387-397. doi: 10.1016/j.actbio.2005.04.002
31. [31]
  R. Tian, J. Chen, R. Niu, Nanoscale 6 (2014) 3474-3482. doi: 10.1039/c3nr05414d
32. [32]
  H. Wang, C. Yang, L. Wang, et al., Chem. Commun. 47 (2011) 4439-4441. doi: 10.1039/c1cc10506j
33. [33]
  R. Bawa, S.Y. Fung, A. Shiozaki, et al., Nanomedicine 8 (2012) 647-654. doi: 10.1016/j.nano.2011.08.007
34. [34]
  D. Ciumac, H. Gong, X. Hu, J.R. Lu, J. Colloid Interface Sci. 537 (2019) 163-185. doi: 10.1016/j.jcis.2018.10.103
1. [1]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
2. [2]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
3. [3]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
4. [4]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
5. [5]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
6. [6]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
7. [7]
  Si Ha , Jiacheng Zhu , Hua Xiang , Guoshun Luo . Hydrophobic tag tethering degrader as a promising paradigm of protein degradation: Past, present and future perspectives. Chinese Chemical Letters, 2024, 35(8): 109192-. doi: 10.1016/j.cclet.2023.109192
8. [8]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
9. [9]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
10. [10]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
11. [11]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
12. [12]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
13. [13]
  Yinglan Yu , Sajid Hussain , Jianping Qi , Lei Luo , Xuemei Zhang . Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells. Chinese Chemical Letters, 2024, 35(12): 109673-. doi: 10.1016/j.cclet.2024.109673
14. [14]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
15. [15]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
16. [16]
  Haijun Shen , Yi Qiao , Chun Zhang , Yane Ma , Jialing Chen , Yingying Cao , Wenna Zheng . A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing. Chinese Chemical Letters, 2024, 35(12): 110283-. doi: 10.1016/j.cclet.2024.110283
17. [17]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
18. [18]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
19. [19]
  Weiyu Chen , Zenghui Li , Chenguang Zhao , Lisha Zha , Junfeng Shi , Dan Yuan . Enzyme-modulate conformational changes in amphiphile peptide for selectively cell delivery. Chinese Chemical Letters, 2024, 35(12): 109628-. doi: 10.1016/j.cclet.2024.109628
20. [20]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(566)
HTML views(76)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142