Citation: Xiao Yang, Fan Zhang, Yue Du, Weitong Cui, Yikai Dou, Yunfeng Lin, Zhihe Zhao, Xiaohong Ma. Effect of tetrahedral DNA nanostructures on LPS‐induced neuroinflammation in mice[J]. Chinese Chemical Letters, ;2022, 33(4): 1901-1906. doi: 10.1016/j.cclet.2021.10.029 shu

Effect of tetrahedral DNA nanostructures on LPS‐induced neuroinflammation in mice

Xiao Yang ^{a, 1} ,
Fan Zhang ^{b, c, 1} ,
Yue Du ^a ,
Weitong Cui ^b ,
Yikai Dou ^a ,
Yunfeng Lin ^{b, d, *,} ,
Zhihe Zhao ^{b, *,} ,
Xiaohong Ma ^{a, **,}

a.
Psychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China
b.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
c.
Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, China
d.
College of Biomedical Engineering, Sichuan University, Chengdu 610041, China

^**

yunfenglin@scu.edu.cn

zhzhao@scu.edu.cn

maxiaohong@scu.edu.cn

Received Date: 17 September 2021
Revised Date: 11 October 2021
Accepted Date: 13 October 2021
Available Online: 21 October 2021

Figures(4)

Neuroinflammation plays a significant role in inducing depression-like behavior. Tetrahedral DNA nanostructures (TDNs) are molecules that exhibit anti-inflammatory properties and can effectively penetrate the blood-brain barrier. Thus, researchers have hypothesized that TDNs regulate the secretion of proinflammatory cytokines and consequently alleviate depression-like behavior. To test this hypothesis, we investigated the effect of TDNs on the depression-like behavior of C57 mice induced by lipopolysaccharide (LPS). We performed open-field, tail suspension, and sucrose preference tests on LPS- and LPS/TDN-treated mice. The results indicated that the injection of TDNs into LPS-treated mice resulted in increased velocity, center zone duration, frequency to the center zone, and sucrose preference, and decreased immobility time. Immunofluorescence results indicated that peripheral administration of LPS in the mice activated inflammation, which culminated in distinct depression-like behavior. However, TDNs effectively alleviated the inflammation and depression-like behavior through the reduction of the expression levels of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α in the brain. Additionally, TDNs normalized the expression level of microglia cell activation markers, such as ionized calcium binding adaptor molecule 1, in the hippocampus of mice. These results indicated that TDNs attenuated the LPS-induced secretion of inflammatory factors and consequently alleviated depression-like behavior.
- Tetrahedral DNA nanostructures,
- Lipopolysaccharide,
- Depression-like behavior,
- Proinflammatory cytokine,
- Microglia cell
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