Citation: Xiang Cheng, Shuai Huang, Qian Lei, Fei Chen, Fan Zheng, Shibo Zhong, Xueyan Huang, Bin Feng, Xueping Feng, Wenbin Zeng. The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(Ⅱ) detection and poisoning[J]. Chinese Chemical Letters, ;2022, 33(4): 1861-1864. doi: 10.1016/j.cclet.2021.10.024 shu

The exquisite integration of ESIPT, PET and AIE for constructing fluorescent probe for Hg(Ⅱ) detection and poisoning

Xiang Cheng ^{a, b, c} ,
Shuai Huang ^{a, b, c} ,
Qian Lei ^{a, b, c} ,
Fei Chen ^{a, b, c} ,
Fan Zheng ^{a, b, c} ,
Shibo Zhong ^{a, b, c} ,
Xueyan Huang ^{a, b, c} ,
Bin Feng ^{a, b, c} ,
Xueping Feng ^d ,
Wenbin Zeng ^{a, b, c, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
The Molecular Imaging Research Center, Central South University, Changsha 410013, China
c.
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha 410013, China
d.
Xiangya Hospital, Central South University, Changsha 410013, China

wbzeng@hotmail.com

Received Date: 21 August 2021
Revised Date: 30 September 2021
Accepted Date: 11 October 2021
Available Online: 16 October 2021

Figures(6)

Excessive mercury ions (Hg²⁺) in the environment can accumulate in human body along with the food chain to cause serious physiological reactions. The fluorescence probes were considered as convenient tool with great potential for Hg²⁺ detection. Most existing probes suffer from aggregation-induced quenching (ACQ) effects and insufficient sensitivity. Herein, a novel type of fluorophore was developed by combining the aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT) characteristics. Subsequently, a phenyl thioformate group with photoinduced electron transfer (PET) effect was connected to give an efficient "turn-on" probe (HTM), which exhibited good selectivity toward Hg²⁺, short response time (30 min), coupled with extremely low detection limit (LOD = 1.68 nmol/L). In addition, HTM was used successfully in real samples, cells and drug evaluation, underlying the superiority of HTM to detect Hg²⁺ in practical applications.
- Aggregation-induced emission,
- Excited state intramolecular proton transfer,
- Photoinduced electron transfer,
- Mercury ions,
- Fluorescent imaging
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沈阳化工大学材料科学与工程学院沈阳 110142