Citation: Tong Liu, Guiting Liu, Jianhua Zhang, Zhangfan Ding, Yike Li, Krishna Sigdel, Xiaoyi Wang, Huixu Xie. L-Arginine based polyester amide/hyaluronic acid hybrid hydrogel with dual anti-inflammation and antioxidant functions for accelerated wound healing[J]. Chinese Chemical Letters, ;2022, 33(4): 1880-1884. doi: 10.1016/j.cclet.2021.10.022 shu

L-Arginine based polyester amide/hyaluronic acid hybrid hydrogel with dual anti-inflammation and antioxidant functions for accelerated wound healing

Tong Liu ^{a, 1} ,
Guiting Liu ^{b, 1} ,
Jianhua Zhang ^c ,
Zhangfan Ding ^a ,
Yike Li ^a ,
Krishna Sigdel ^a ,
Xiaoyi Wang ^{a, *,} ,
Huixu Xie ^{a, *,}

a.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
The State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China
c.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

wangxy0128@126.com

aitian007@126.com

Received Date: 21 August 2021
Revised Date: 1 October 2021
Accepted Date: 11 October 2021
Available Online: 16 October 2021

Figures(3)

Nowadays, there are still many challenges to skin regeneration. As a new type of skin substitute, hydrogel has emerging gradually with its excellent properties. However, it is still a challenge to combine with biological active agents to facilitate skin regeneration. Under the circumstance, we synthesized arginine-based poly(ester amide) (Arg-PEA) and hyaluronic acid (HA-MA), and combined them into new hybrid hydrogels via photo-crosslinking. We found that the internal structure and physicochemical properties of hybrid hydrogels were greatly improved with the increase of content of Arg-PEA. Therefore, we designed hybrid hydrogels with 5 wt% and 10 wt% of Arg-PEA content, respectively. Besides, we selected the corresponding anti-inflammatory (CRP, TNF-α) indicators to detect the anti-inflammatory properties of the hybrid hydrogels at the protein level, and the corresponding antioxidant indicators (SOD, GSH/GSSG, MDA) were selected to investigate the antioxidant properties of hybrid hydrogels at the cellular level in vitro. In addition, we also selected relevant genes to test the effect of hybrid hydrogels on fibrosis and vascularization in the process of skin wound healing in vitro and verified them in vivo with a mouse dorsum wound model. The results confirmed that Arg-PEA/HA-MA (AH) hybrid hydrogel was a prospective scaffold material for skin regeneration.
- Hydrogel,
- Skin wound healing,
- Antioxidant,
- Anti-inflammation
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