Citation: Xinying Yu, Tongyi Shang, Guodong Zheng, Hailong Yang, Yuwei Li, Yanjun Cai, Guoxi Xie, Bin Yang. Metal-polyphenol-coordinated nanomedicines for Fe(II) catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer[J]. Chinese Chemical Letters, ;2022, 33(4): 1895-1900. doi: 10.1016/j.cclet.2021.10.021 shu

Metal-polyphenol-coordinated nanomedicines for Fe(II) catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer

The Sixth Affiliated Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China

guoxixie@163.com

bin.yang@gzhmu.edu.cn

Received Date: 9 August 2021
Revised Date: 5 October 2021
Accepted Date: 11 October 2021
Available Online: 16 October 2021

Figures(5)

Ferroustherapy has gained great attention for anti-cancer treatment in recent years. Enlightened by temperature-mediated Fenton reaction in industrial waste water removal, we designed a iron-based polyphenol-coordinated nanomedicines for mild hyperthermia-assisted anti-cancer ferroustherapy. In brief, Fe-GA@BSA nanoparticles was synthesized by self-assembly and sorafenib (SRF) was loaded into Fe-GA@BSA to establish Fe-GA@BSA-SRF nanomedicines. The result nanomedicines can induce ferroptosis in cancer cells by accelerating Fenton reaction. And the photothermal effect of Fe-GA@BSA-SRF was used for mild hyperthermia-assisted ferroustherapy. The nanomedicines performs good anti-cancer therapeutic efficacy by inducing the production of ROS and inhibiting glutathione peroxidase 4 (GPX4) expression in vitro and in vivo. Besides, the broad absorption of Fe-GA@BSA-SRF in near infrared region endows it with photoacoustic imaging ability. This study provides ideas about rational design on iron-based nanoparticles for anti-cancer ferroustherapy.
- Ferroptosis,
- Metal-polyphenol nanomedicines,
- Fenton reaction,
- Mild hyperthermia,
- Photoacoustic imaging
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