Citation: Hedong Qi, Yuwei Xu, Pin Hu, Chi Yao, Dayong Yang. Construction and applications of DNA-based nanomaterials in cancer therapy[J]. Chinese Chemical Letters, ;2022, 33(3): 1131-1140. doi: 10.1016/j.cclet.2021.09.026 shu

Construction and applications of DNA-based nanomaterials in cancer therapy

Hedong Qi ¹ ,
Yuwei Xu ¹ ,
Pin Hu ,
Chi Yao ^*, ,
Dayong Yang ^*,

Frontiers Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China

Author Bio: Hedong Qi received his B.E. degree at College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology in 2018. He is currently a graduate student in Prof. Dayong Yang's Lab. His-current research focuses on DNA functional materials
Yuwei Xu received her B.E. degree at Hebei University of Technology in 2019. She is currently a graduate student in Prof. Dayong Yang's Lab. Her current research focuses on DNA functional materials
Pin Hu received her B.E. degree from the College of Food Science and Technology of Nanjing Agricultural University in 2018. She is currently a graduate student in Prof. Dayong Yang's Lab. Her current research focuses on DNA functional materials
Chi Yao is an associate professor in the School of Chemical Engineering and Technology of Tianjin University. She obtained her Ph.D. degree from Fudan University in 2017. Her current research focuses on DNA functional materials and analytical chemistry
Dayong Yang is a professor in the School of Chemical Engineering and Technology of Tianjin University. He received his B.S. and M.S. degrees at Huazhong University of Science and Technology of China in 2002 and 2005, respectively. In 2008, he received his Ph.D. degree at the National Center for Nanoscience and Technology, Chinese Academy of Sciences. He did postdoctoral training at Cornell University in the USA and Radboud Universiteit Nijmegen in The Netherlands. The themes of his research include DNA materials, biofunctional polymers, and synthetic biology

chi.yao@tju.edu.cn

dayong.yang@tju.edu.cn

Received Date: 7 June 2021
Revised Date: 4 September 2021
Accepted Date: 6 September 2021
Available Online: 10 September 2021

Figures(7)

As a biologically active macromolecule, deoxyribonucleic acid (DNA) has the advantages of sequence programmability and structure controllability and can accurately transmit sequence information to specific biological functions. Facing the complex internal microenvironment and heterogeneity in tumor treatment, the construction and applications of DNA-based nanomaterials have become a focus point of research. In particular, the hybridization of DNA molecules with other materials endows DNA-based nanomaterials with multiple functions such as targeting, stimulus responsiveness and regulations of biological activities, making DNA nanostructures great potential in the treatment of major human diseases. In this review, the construction and characteristics of DNA-based nanomaterials are introduced. Then, the functions and applications of DNA-based nanomaterials in the delivery of chemotherapy drugs and gene drugs, stimulus-responsive release and regulation of cell homeostasis are reviewed. Finally, the future development and challenges of DNA-based nanomaterials are prospected. We envision that DNA-based nanomaterials can enrich the nanomaterial system by rational design and synthesis and address the growing demands on biological and biomedical applications in the real world.
- DNA nanomaterials,
- DNA nanotechnology,
- Drug delivery,
- Cancer therapy
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