Citation: Mingzhu Liu, Liang Xu, Yu Wei. Electrochemical utilization of methanol and methanol-d₄ as a C1 source to access (deuterated) 2, 3-dihydroquinazolin-4(1H)-one[J]. Chinese Chemical Letters, ;2022, 33(3): 1559-1562. doi: 10.1016/j.cclet.2021.09.019 shu

Electrochemical utilization of methanol and methanol-d₄ as a C1 source to access (deuterated) 2, 3-dihydroquinazolin-4(1H)-one

School of Chemistry and Chemical Engineering, Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832003, China

xuliang4423@shzu.edu.cn

yuweichem@shzu.edu.cn

Received Date: 23 June 2021
Revised Date: 2 September 2021
Accepted Date: 3 September 2021
Available Online: 10 September 2021

Figures(6)

Herein, an electrocatalytic protocol for the synthesis of 2, 3-dihydroquinazolin-4(1H)-one has been disclosed. Methanol is activated and utilized as the C1 source to cyclize with 2-aminobenzamides. This cyclization reaction proceeds conveniently (room temperature and air atmosphere) without any homogeneous metal catalysts, external oxidants, or bases. A wide variety of N, N-disubstituted 2, 3-dihydroquinazolin-4(1H)-ones are obtained via this approach. Moreover, when methanol-d₄ is used, a deuterated methylene motif is incorporated into the N-heterocycles, providing an efficient approach to the deuterated N-heterocycles.
- Electrochemistry,
- Heterocycles,
- Dihydroquinazolinone,
- Aminobenzamide,
- C1 source
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Electrochemical utilization of methanol and methanol-d4 as a C1 source to access (deuterated) 2, 3-dihydroquinazolin-4(1H)-one

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通讯作者: 陈斌, bchen63@163.com

Electrochemical utilization of methanol and methanol-d₄ as a C1 source to access (deuterated) 2, 3-dihydroquinazolin-4(1H)-one