Citation: Rongjun Zhang, Youbin Zheng, Tianqing Liu, Ning Tang, Lianzhi Mao, Lihan Lin, Jiahui Ye, Luoyijun Xie, Wenwen Hu, Weiwei Wu, Wenzhen Liao, Miaomiao Yuan. The marriage of sealant agent between structure transformable silk fibroin and traditional Chinese medicine for faster skin repair[J]. Chinese Chemical Letters, ;2022, 33(3): 1599-1603. doi: 10.1016/j.cclet.2021.09.018 shu

The marriage of sealant agent between structure transformable silk fibroin and traditional Chinese medicine for faster skin repair

Rongjun Zhang ^{a, b, 1} ,
Youbin Zheng ^{c, 1} ,
Tianqing Liu ^{d, 1} ,
Ning Tang ^{d, 1} ,
Lianzhi Mao ^e ,
Lihan Lin ^a ,
Jiahui Ye ^a ,
Luoyijun Xie ^a ,
Wenwen Hu ^d ,
Weiwei Wu ^{d, *,} ,
Wenzhen Liao ^{e, *,} ,
Miaomiao Yuan ^{a, *,}

a.
The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China
b.
Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China
c.
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Isr1ael Institute of Technology, Haifa 3200003, Israel
d.
School of Advanced Materials and Nanotechnology, Interdisciplinary Research Center of Smart Sensors, Xidian University, Xi'an 710126, China
e.
Department of Nutrition and Food Hygiene, School of Public Health, Southern Medical University, Guangzhou 510515, China

wwwu@xidian.edu.cn

wenzhenliao@163.com

yuanmm2019@163.com

Received Date: 5 June 2021
Revised Date: 1 September 2021
Accepted Date: 3 September 2021
Available Online: 10 September 2021

Figures(4)

Fast skin repair is critical for less infection, less pain and high quality of life, which is still limited with undesirable rehabilitation speed and side effects. Currently, laser-activated silk sealant agent without suture and gauze has been demonstrated promising for fast skin repair taking advantage of its structural transformation after heating. Nevertheless, more efficient healing effects and less side effects of laser-activated silk sealant agent remains challenging due to absence of suitable photo-thermal materials and robust/biomimetic protein materials. In this work, the marriage between silk protein and Rehmanniae radix preparata (a kind of the traditional Chinese herb) has been demonstrated as a novel and effective way to achieve an excellent healing effect for skin repair. The non-toxicity, high photothermal conversion efficiency and healing mechanism are systematically studied and proved. This new methodology might shed a new light for combining dark traditional Chinese medicine and silk fibroin for advanced wound healing technology.
- Rehmanniae radix preparata,
- Silk fibroin,
- Sealant agent,
- Photo-thermal effect,
- Skin repair
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