Citation: Yuxun Lu, Jiajia Xu, Zongyun Jia, Siyu Kong, Yimu Qiao, Lin Li, Qiong Wu, Ying Zhou. A near-infrared multifunctional fluorescent probe for hypoxia monitoring and tumor-targeted therapy[J]. Chinese Chemical Letters, ;2022, 33(3): 1589-1594. doi: 10.1016/j.cclet.2021.09.013 shu

A near-infrared multifunctional fluorescent probe for hypoxia monitoring and tumor-targeted therapy

Yuxun Lu ^{a, 1} ,
Jiajia Xu ^{b, 1} ,
Zongyun Jia ^a ,
Siyu Kong ^a ,
Yimu Qiao ^a ,
Lin Li ^b ,
Qiong Wu ^{b, *,} ,
Ying Zhou ^{a, 1,}

a.
College of Chemical Science and Technology, Yunnan University, Kunming 650091, China
b.
Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China

iamqwu@njtech.edu.cn

yingzhou@ynu.edu.cn

Received Date: 5 July 2021
Revised Date: 1 September 2021
Accepted Date: 1 September 2021
Available Online: 8 September 2021

Figures(6)

Hypoxia is one of the key characteristics of solid tumors. The over-expression of azoreductase resulting from hypoxia can be used as a target to visualize hypoxic levels and a trigger of the drug release system in tumor treatment. In this work, we developed a near-infrared fluorescent probe YLOD, composed of a near-infrared fluorophore, an azo bond, and an analogue of the anti-tumor drug melphalan. In the presence of azoreductase, YLOD displayed a red emission at 620 nm and released the anti-tumor drug concomitantly, thus achieving the integrated effects of hypoxic imaging and tumor treatment. Furthermore, YLOD successfully inhibited the growth of solid tumors during the tumor suppression experiments in nude mice. Considering all the results, YLOD emerges as a new fluorescence tool that can quickly determine the location and the edges of a tumor, showing concrete potential in clinical cancer treatment.
- Azoreductase,
- Hypoxia,
- Theranostic,
- Tumor
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