Citation: Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding, Wenhu Zhou. Macrophage-targeted nanomedicine for chronic diseases immunotherapy[J]. Chinese Chemical Letters, ;2022, 33(2): 597-612. doi: 10.1016/j.cclet.2021.08.090 shu

Macrophage-targeted nanomedicine for chronic diseases immunotherapy

Yuejia Song ^{a, 1} ,
Yaqian Huang ^{a, 1} ,
Fang Zhou ^c ,
Jinsong Ding ^{a, *,} ,
Wenhu Zhou ^{a, b, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Academician Workstation, Changsha Medical University, Changsha 410219, China
c.
Department of Pharmacy, Southern University of Science and Technology Hospital, Shenzhen 518055, China

dingjs0221@163.com

zhouwenhuyaoji@163.com

Received Date: 5 June 2021
Revised Date: 11 August 2021
Accepted Date: 18 August 2021
Available Online: 22 August 2021

Figures(14)

Macrophage is the key innate immune effector in first-line defense against the pathogens, and can be polarized into different phenotypes to regulate a variety of immunological functions. However, the plasticity of macrophage is extraordinarily recruited, activated, and polarized under pathological conditions, playing paramount roles in occurrence, development, and prognosis of various chronic diseases, such as rheumatoid arthritis (RA), atherosclerosis (AS), and cancer. To this end, macrophage has become an important therapeutic target for etiological treatment of these diseases. Meanwhile, with the development of nanotechnology, various nano-drug delivery systems have been explored to target macrophages for disease modulation, displaying unique advantages to address both pharmaceutic and biopharmaceutic limitations of various drugs. This review aims to summarize the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy. First, the origin, polarization and biological functions of macrophages have been introduced, in which macrophages can differentiate into different phenotypes in response to physiological stimuli to play various immunological roles. Then, the macrophage disorder has been reviewed in related with various chronic diseases, and several representative diseases, including AS, RA, obesity, and cancer, have been discussed in detail to elucidate the pathological contributions of macrophages for disease progress. Next, strategies to regulate macrophages for diseases immunotherapy, such as macrophages depletion, macrophage reprograming, inhibition of macrophage recruitment, are summarized, and particular attention has been paid on bio-functional nanomaterials to engineer macrophages via different mechanisms. Further, methods for macrophage-targeting delivery nanosystems are discussed based on both passive and active targeting approaches. Finally, the perspective is speculated for potential clinical translation, and there still has significant room for the development of novel macrophage-targeting nanomedicine for precise, effective, and biosafe therapy.
- Nanoparticles,
- Delivery,
- Macrophages,
- Polarization,
- Immunotherapy
1. [1]
  W.B. Coley, Proc. R. Soc. Med. 3(1910) 1-48.
2. [2]
  W. Chen, Y. Wu, Q. Lu, S. Wang, D. Xing, Clin. Chim. Acta 505(2020) 55-59. doi: 10.1016/j.cca.2020.02.025
3. [3]
  I. Sergin, T.D. Evans, X. Zhang, et al., Nat. Commun. 8(2017) 15750. doi: 10.1038/ncomms15750
4. [4]
  P.J. Murray, T.A. Wynn, Nat. Rev. Immunol. 11(2011) 723-737. doi: 10.1038/nri3073
5. [5]
  K. Molawi, Y. Wolf, P.K. Kandalla, et al., J. Exp. Med. 211(2014) 2151-2158. doi: 10.1084/jem.20140639
6. [6]
  L.C. Davies, S.J. Jenkins, J.E. Allen, P.R. Taylor, Nat. Immunol. 14(2013) 986-995. doi: 10.1038/ni.2705
7. [7]
  M.A. Lameijer, J. Tang, M. Nahrendorf, R.H.J. Beelen, W.J.M. Mulder, Expert Rev. Mol. Diagn. 13(2014) 567-580.
8. [8]
  M. de Palma, C.E. Lewis, Cancer Cell 23(2013) 277-286. doi: 10.1016/j.ccr.2013.02.013
9. [9]
  C.I. Diakos, K.A. Charles, D.C. McMillan, S.J. Clarke, Lancet Oncol. 15(2014) E493-E503. doi: 10.1016/S1470-2045(14)70263-3
10. [10]
  G. Germano, R. Frapolli, C. Belgiovine, et al., Cancer Cell 23(2013) 249-262. doi: 10.1016/j.ccr.2013.01.008
11. [11]
  G.S. Firestein, Nature 423(2003) 356-361. doi: 10.1038/nature01661
12. [12]
  R.W. Kinne, R. Brauer, B. Stuhlmuller, E. Palombo-Kinne, G.R. Burmester, Arthritis Res. 2(2000) 189-202. doi: 10.1186/ar86
13. [13]
  G.S. Hotamisligil, Nature 444(2006) 860-867. doi: 10.1038/nature05485
14. [14]
  K.J. Moore, F.J. Sheedy, E.A. Fisher, Nat. Rev. Immunol. 13(2013) 709-721. doi: 10.1038/nri3520
15. [15]
  J.M. Olefsky, C.K. Glass, Annu. Rev. Physiol. 72(2010) 219-246. doi: 10.1146/annurev-physiol-021909-135846
16. [16]
  A. Castoldi, C.N. de Souza, N.O. Saraiva Camara, P.M. Moraes-Vieira, Front. Immunol. 6(2016) 11.
17. [17]
  H. Koppensteiner, R. Brack-Werner, M. Schindler, Retrovirology 9(2012) 11. doi: 10.1186/1742-4690-9-11
18. [18]
  A. Kumar, G. Herbein, Mol. Cell. Ther. 2(2014) 10. doi: 10.1186/2052-8426-2-10
19. [19]
  C. Bi, Y. Fu, B. Li, Cell. Signal. 70(2020) 109569. doi: 10.1016/j.cellsig.2020.109569
20. [20]
  K. Rahman, Y. Vengrenyuk, S.A. Ramsey, et al., J. Clin. Invest. 127(2017) 2904-2915. doi: 10.1172/JCI75005
21. [21]
  C. Shi, T. Liu, Z. Guo, et al., Nano Lett. 18(2018) 7330-7342. doi: 10.1021/acs.nanolett.8b03568
22. [22]
  V.M.T. Bart, R.J. Pickering, P.R. Taylor, N. Ipseiz, Immunology 163(2021) 128-144. doi: 10.1111/imm.13300
23. [23]
  S. Cousin, J. Seneschal, A. Italiano, Pharmacol. Ther. 181(2018) 91-100. doi: 10.1016/j.pharmthera.2017.07.005
24. [24]
  A. Taki, P. Smooker, Vaccines 3(2015) 638-661. doi: 10.3390/vaccines3030638
25. [25]
  C. Kaittanis, T.M. Shaffer, D.L.J. Thorek, J. Grimm, Crit. Rev. Oncog. 19(2014) 143-176. doi: 10.1615/CritRevOncog.2014011601
26. [26]
  A. Mahapatro, D.K. Singh, J. Nanobiotechnol. 9(2011) 55. doi: 10.1186/1477-3155-9-55
27. [27]
  M.D. Newman, M. Stotland, J.I. Ellis, J. Am. Acad. Dermatol. 61(2009) 685-692. doi: 10.1016/j.jaad.2009.02.051
28. [28]
  D.R. Getts, L.D. Shea, S.D. Miller, N.J.C. King, Trends Immunol. 36(2015) 419-427. doi: 10.1016/j.it.2015.05.007
29. [29]
  X. Zheng, J. Xie, X. Zhang, et al., Chin. Chem. Lett. 32(2021) 243-257. doi: 10.1016/j.cclet.2020.11.029
30. [30]
  M.S. Dukhinova, A.Y. Prilepskii, A.A. Shtil, V.V. Vinogradov, Nanomaterials (Basel) 9(2019) 1631. doi: 10.3390/nano9111631
31. [31]
  K.R. Peterson, M.A. Cottam, A.J. Kennedy, A.H. Hasty, Trends Pharmacol. Sci. 39(2018) 536-546. doi: 10.1016/j.tips.2018.03.001
32. [32]
  J. Zhao, X. Chen, K.H. Ho, et al., Chin. Chem. Lett. 32(2021) 66-86. doi: 10.1016/j.cclet.2020.11.048
33. [33]
  X. Zang, M. Cheng, X. Zhang, X. Chen, J. Mater. Chem. B 9(2021) 3284-3294. doi: 10.1039/D0TB02956D
34. [34]
  Y. Xia, L. Rao, H. Yao, et al., Adv. Mater. 32(2020) e2002054. doi: 10.1002/adma.202002054
35. [35]
  M. Sylvestre, C.A. Crane, S.H. Pun, Adv. Mater. 32(2020) e1902007. doi: 10.1002/adma.201902007
36. [36]
  A. Shapouri-Moghaddam, S. Mohammadian, H. Vazini, et al., J. Cell. Physiol. 233(2018) 6425-6440.
37. [37]
  C.D. Mills, K. Ley, J. Innate Immun. 6(2014) 716-726. doi: 10.1159/000364945
38. [38]
  S.K. Biswas, A. Mantovani, Nat. Immunol. 11(2010) 889-896. doi: 10.1038/ni.1937
39. [39]
  D.M. Mosser, J.P. Edwards, Nat. Rev. Immunol. 8(2008) 958-969. doi: 10.1038/nri2448
40. [40]
  C.D. Mills, Crit. Rev. Immunol. 32(2012) 463-488. doi: 10.1615/CritRevImmunol.v32.i6.10
41. [41]
  J.J. Boyle, H.A. Harrington, E. Piper, et al., Am. J. Pathol. 174(2009) 1097- 1108. doi: 10.2353/ajpath.2009.080431
42. [42]
  A. Kadl, A.K. Meher, P.R. Sharma, et al., Circ. Res. 107(2010) 737-U155. doi: 10.1161/CIRCRESAHA.109.215715
43. [43]
  G. Chinetti-Gbaguidi, S. Colin, B. Staels, Nat. Rev. Cardiol. 12(2015) 10-17. doi: 10.1038/nrcardio.2014.173
44. [44]
  P.J. Murray, Annu. Rev. Physiol. 79(2017) 541-566. doi: 10.1146/annurev-physiol-022516-034339
45. [45]
  A. Sica, A. Mantovani, J. Clin. Invest. 122(2012) 787-795. doi: 10.1172/JCI59643
46. [46]
  X. Zhang, D.M. Mosser, J. Pathol. 214(2008) 161-178. doi: 10.1002/path.2284
47. [47]
  T. Lawrence, G. Natoli, Nat. Rev. Immunol. 11(2011) 750-761. doi: 10.1038/nri3088
48. [48]
  C.A. Ambarus, S. Krausz, M. van Eijk, et al., J. Immunol. Methods. 375(2012) 196-206. doi: 10.1016/j.jim.2011.10.013
49. [49]
  M. Jaguin, N. Houlbert, O. Fardel, V. Lecureur, Cell Immunol. 281(2013) 51-61. doi: 10.1016/j.cellimm.2013.01.010
50. [50]
  D.M. Mosser, J. Leukoc. Biol. 73(2003) 209-212. doi: 10.1189/jlb.0602325
51. [51]
  A. Mantovani, S.K. Biswas, M.R. Galdiero, A. Sica, M. Locati, J. Pathol. 229(2013) 176-185. doi: 10.1002/path.4133
52. [52]
  E.M. Conway, D. Collen, P. Carmeliet, Cardiovasc. Res. 49(2001) 507-521. doi: 10.1016/S0008-6363(00)00281-9
53. [53]
  T.A. Wynn, L. Barron, Semin. Liver Dis. 30(2010) 245-257. doi: 10.1055/s-0030-1255354
54. [54]
  H.Y. Zhao, Y.Y. Zhang, T. Xing, et al., Signal Transduct. Tar. 6(2021) 234. doi: 10.1038/s41392-021-00627-y
55. [55]
  T. Rőszer, Mediators Inflamm. 2015(2015) 816460.
56. [56]
  R. Klopfleisch, Acta Biomater. 43(2016) 3-13. doi: 10.1016/j.actbio.2016.07.003
57. [57]
  K.A. Jablonski, S.A. Amici, L.M. Webb, et al., PLoS One 10(2015) e0145342. doi: 10.1371/journal.pone.0145342
58. [58]
  L.X. Wang, S.X. Zhang, H.J. Wu, X.L. Rong, J. Guo, J. Leukoc. Biol. 106(2019) 345-358. doi: 10.1002/JLB.3RU1018-378RR
59. [59]
  J.S. Orr, A. Kennedy, E.K. Anderson-Baucum, et al., Diabetes 63(2014) 421-432. doi: 10.2337/db13-0213
60. [60]
  C.A. Gleissner, I. Shaked, K.M. Little, K. Ley, J. Immunol. 184(2010) 4810-4818. doi: 10.4049/jimmunol.0901368
61. [61]
  P. Shashkin, B. Dragulev, K. Ley, Curr. Pharm. Des. 11(2005) 3061-3072. doi: 10.2174/1381612054865064
62. [62]
  P. Libby, Nature 420(2002) 868-874. doi: 10.1038/nature01323
63. [63]
  K.C. Navegantes, R. de Souza Gomes, P.A.T. Pereira, et al., J. Transl. Med. 15(2017) 36. doi: 10.1186/s12967-017-1141-8
64. [64]
  L. Ye, Z. Wen, Y. Li, et al., Arthritis Res. Ther. 16(2014) R96. doi: 10.1186/ar4544
65. [65]
  I.A. Udalova, A. Mantovani, M. Feldmann, Nat. Rev. Rheumatol. 12(2016) 472-485. doi: 10.1038/nrrheum.2016.91
66. [66]
  I.B. McInnes, G. Schett, Nat. Rev. Immunol. 7(2007) 429-442. doi: 10.1038/nri2094
67. [67]
  I.B. McInnes, G. Schett, Lancet 389(2017) 2328-2337. doi: 10.1016/S0140-6736(17)31472-1
68. [68]
  S.P. Weisberg, D. McCann, M. Desai, et al., J. Clin. Invest. 112(2003) 1796-1808. doi: 10.1172/JCI200319246
69. [69]
  H.Y. Xu, G.T. Barnes, Q. Yang, et al., J. Clin. Invest. 112(2003) 1821-1830. doi: 10.1172/JCI200319451
70. [70]
  S. Cinti, G. Mitchell, G. Barbatelli, et al., J. Lipid Res. 46(2005) 2347-2355. doi: 10.1194/jlr.M500294-JLR200
71. [71]
  A.J. Mouton, X. Li, M.E. Hall, J.E. Hall, Circ. Res. 126(2020) 789-806. doi: 10.1161/CIRCRESAHA.119.312321
72. [72]
  L. Russo, C.N. Lumeng, Immunology 155(2018) 407-417. doi: 10.1111/imm.13002
73. [73]
  T. McLaughlin, S.E. Ackerman, L. Shen, E. Engleman, J. Clin. Invest. 127(2017) 5-13. doi: 10.1172/JCI88876
74. [74]
  N. Kamei, K. Tobe, R. Suzuki, et al., J. Biol. Chem. 281(2006) 26602-26614. doi: 10.1074/jbc.M601284200
75. [75]
  M. Spite, J. Hellmann, Y. Tang, et al., J. Immunol. 187(2011) 1942-1949. doi: 10.4049/jimmunol.1100196
76. [76]
  A. Castoldi, C. Naffah de Souza, N.O. Camara, P.M. Moraes-Vieira, Front. Immunol. 6(2015) 637.
77. [77]
  X. Xu, A. Grijalva, A. Skowronski, et al., Cell Metab. 18(2013) 816-830. doi: 10.1016/j.cmet.2013.11.001
78. [78]
  K.W. Cho, D.L. Morris, J.L. DelProposto, et al., Cell Rep. 9(2014) 605-617. doi: 10.1016/j.celrep.2014.09.004
79. [79]
  D.L. Morris, K.W. Cho, J.L. Delproposto, et al., Diabetes 62(2013) 2762-2772. doi: 10.2337/db12-1404
80. [80]
  M. Kratz, B.R. Coats, K.B. Hisert, et al., Cell Metab. 20(2014) 614-625. doi: 10.1016/j.cmet.2014.08.010
81. [81]
  B.R. Coats, K.Q. Schoenfelt, V.C. Barbosa-Lorenzi, et al., Cell Rep. 20(2017) 3149-3161. doi: 10.1016/j.celrep.2017.08.096
82. [82]
  J.P. Edwards, X. Zhang, K.A. Frauwirth, D.M. Mosser, J. Leukoc. Biol. 80(2006) 1298-1307. doi: 10.1189/jlb.0406249
83. [83]
  A. Mantovani, F. Marchesi, A. Malesci, L. Laghi, P. Allavena, Nat. Rev. Clin. Oncol. 14(2017) 399-416. doi: 10.1038/nrclinonc.2016.217
84. [84]
  G. Solinas, G. Germano, A. Mantovani, P. Allavena, J. Leukoc. Biol. 86(2009) 1065-1073. doi: 10.1189/jlb.0609385
85. [85]
  J.L. Owen, M. Mohamadzadeh, Front. Physiol. 4(2013) 159.
86. [86]
  R. Noy, J.W. Pollard, Immunity 41(2014) 49-61. doi: 10.1016/j.immuni.2014.06.010
87. [87]
  N. Cheng, X. Bai, Y. Shu, O. Ahmad, P. Shen, Biochem. Pharmacol. 183(2021) 114354. doi: 10.1016/j.bcp.2020.114354
88. [88]
  Q. Yang, N. Guo, Y. Zhou, et al., Acta Pharm. Sin. B 10(2020) 2156-2170. doi: 10.1016/j.apsb.2020.04.004
89. [89]
  K.K. Goswami, T. Ghosh, S. Ghosh, et al., Cell Immunol. 316(2017) 1-10. doi: 10.1016/j.cellimm.2017.04.005
90. [90]
  L. Lin, Y.S. Chen, Y.D. Yao, et al., Oncotarget 6(2015) 34758-34773. doi: 10.18632/oncotarget.5325
91. [91]
  D. Reichel, M. Tripathi, J.M. Perez, Nanotheranostics 3(2019) 66-88. doi: 10.7150/ntno.30052
92. [92]
  D. Zhang, F. Feng, R. Liu, W. Zhu, L. Yao, Chin. Chem. Lett. 30(2019) 7-14. doi: 10.1016/j.cclet.2018.06.011
93. [93]
  Y. Yao, H. Ye, Z. Qi, et al., Clin. Cancer Res. 22(2016) 2778-2790. doi: 10.1158/1078-0432.CCR-15-0858
94. [94]
  S.R. Gordon, R.L. Maute, B.W. Dulken, et al., Nature 545(2017) 495-499. doi: 10.1038/nature22396
95. [95]
  T. Noguchi, J.P. Ward, M.M. Gubin, et al., Cancer Immunol. Res. 5(2017) 106-117. doi: 10.1158/2326-6066.CIR-16-0391
96. [96]
  M. Ponzoni, F. Pastorino, D. Di Paolo, P. Perri, C. Brignole, Int. J. Mol. Sci. 19(2018) 17.
97. [97]
  L. Cassetta, J.W. Pollard, Nat. Rev. Drug Discov. 17(2018) 887-904. doi: 10.1038/nrd.2018.169
98. [98]
  F. Peyraud, S. Cousin, A. Italiano, Curr. Oncol. Rep. 19(2017) 10. doi: 10.1007/s11912-017-0570-0
99. [99]
  S. Shen, H.J. Li, K.G. Chen, et al., Nano Lett. 17(2017) 3822-3829. doi: 10.1021/acs.nanolett.7b01193
100. [100]
  D.C. Strachan, B. Ruffell, Y. Oei, et al., Oncoimmunology 2(2013) e26968. doi: 10.4161/onci.26968
101. [101]
  S.M. Pyonteck, L. Akkari, A.J. Schuhmacher, et al., Nat. Med. 19(2013) 1264-1272. doi: 10.1038/nm.3337
102. [102]
  R. Zhu, L. Su, J. Dai, et al., ACS Nano 14(2020) 3991-4006. doi: 10.1021/acsnano.9b07984
103. [103]
  W. He, N. Kapate, C.W. Shields, S. Mitragotri, Adv. Drug Del. Rev. 165-166(2020) 15-40.
104. [104]
  H. Fleisch, J. Gen. Intern. Med. 116(1989) 1-28.
105. [105]
  J.E. Bader, R.T. Enos, K.T. Velazquez, et al., Am. J. Physiol. 314(2018) G22-G31.
106. [106]
  M. Niu, Y.W. Naguib, A.M. Aldayel, et al., Mol. Pharm. 11(2014) 4425-4436. doi: 10.1021/mp500565q
107. [107]
  F.J. Xu, Chin. Chem. Lett. 30(2019) 2051-2052. doi: 10.1016/j.cclet.2019.10.038
108. [108]
  A. Etzerodt, M.B. Maniecki, J.H. Graversen, et al., J. Control. Release 160(2012) 72-80. doi: 10.1016/j.jconrel.2012.01.034
109. [109]
  S.S. Kim, C. Ye, P. Kumar, et al., Mol. Ther. 18(2010) 993-1001. doi: 10.1038/mt.2010.27
110. [110]
  H. Laroui, E. Viennois, B. Xiao, et al., J. Control. Release 186(2014) 41-53. doi: 10.1016/j.jconrel.2014.04.046
111. [111]
  B. Xiao, H. Laroui, S. Ayyadurai, et al., Biomaterials 34(2013) 7471-7482. doi: 10.1016/j.biomaterials.2013.06.008
112. [112]
  S.H. Wong, J.M. Lord, Arch. Immunol. Ther. Exp. (Warsz.) 52(2004) 379-388.
113. [113]
  C.N. Serhan, S.D. Brain, C.D. Buckley, et al., FASEB J 21(2007) 325-332. doi: 10.1096/fj.06-7227rev
114. [114]
  T.A. Wynn, A. Chawla, J.W. Pollard, Nature 496(2013) 445-455. doi: 10.1038/nature12034
115. [115]
  P.A. Alvarado-Vazquez, L. Bernal, C.A. Paige, et al., Immunobiology 222(2017) 900-912. doi: 10.1016/j.imbio.2017.05.011
116. [116]
  M.C. Li, S.H. He, World J. Gastroenterol. 10(2004) 620-625. doi: 10.3748/wjg.v10.i5.620
117. [117]
  K.W. Moore, R.D. Malefyt, R.L. Coffman, A. O'Garra, Annu. Rev. Immunol. 19(2001) 683-765. doi: 10.1146/annurev.immunol.19.1.683
118. [118]
  S. Jain, T.H. Tran, M. Amiji, Biomaterials 61(2015) 162-177. doi: 10.1016/j.biomaterials.2015.05.028
119. [119]
  J.H. Phillips, G.F. Babcock, K. Nishioka, J. Immunol. 126(1981) 915-921.
120. [120]
  Z. Bar-Shavit, Y. Stabinsky, M. Fridkin, R. Goldman, J. Cell. Physiol. 100(1979) 55-62. doi: 10.1002/jcp.1041000106
121. [121]
  Y. Wang, Y.X. Lin, S.L. Qiao, et al., Biomaterials 112(2017) 153-163. doi: 10.1016/j.biomaterials.2016.09.034
122. [122]
  Y.X. Feng, R.Y. Mu, Z.Z. Wang, et al., Nat. Commun. 10(2019) 14. doi: 10.1038/s41467-018-07865-9
123. [123]
  C.B. Rodell, S.P. Arlauckas, M.F. Cuccarese, et al., Nat. Biomed. Eng. 2(2018) 578-588. doi: 10.1038/s41551-018-0236-8
124. [124]
  S.Y. Kim, S. Kim, J.E. Kim, et al., ACS Nano 13(2019) 12671-12686. doi: 10.1021/acsnano.9b04207
125. [125]
  Z. Huang, Z. Zhang, Y. Jiang, et al., J. Control. Release 158(2012) 286-292. doi: 10.1016/j.jconrel.2011.11.013
126. [126]
  C. Ngambenjawong, H.H. Gustafson, S.H. Pun, Adv. Drug Del. Rev. 114(2017) 206-221. doi: 10.1016/j.addr.2017.04.010
127. [127]
  H.J. Zhao, B.B. Zhao, L.X. Wu, et al., ACS Nano 13(2019) 12553-12566. doi: 10.1021/acsnano.9b03288
128. [128]
  N.N. Parayath, A. Parikh, M.M. Amiji, Nano Lett. 18(2018) 3571-3579. doi: 10.1021/acs.nanolett.8b00689
129. [129]
  S.K. Watkins, N.K. Egilmez, J. Suttles, R.D. Stout, J. Immunol. 178(2007) 1357-1362. doi: 10.4049/jimmunol.178.3.1357
130. [130]
  Y. Wang, Y.X. Lin, S.L. Qiao, et al., Biomaterials 112(2017) 153-163. doi: 10.1016/j.biomaterials.2016.09.034
131. [131]
  J. Hardie, J.A. Mas-Rosario, S.Y. Ha, E.M. Rizzo, M.E. Farkas, Pharmacol. Res. 148(2019) 6.
132. [132]
  Z. Lu, L. Xu, N. He, et al., Chin. Chem. Lett. 30(2019) 1320-1324. doi: 10.1016/j.cclet.2019.03.001
133. [133]
  M.P. Schoen, M. Schoen, Oncogene 27(2008) 190-199. doi: 10.1038/sj.onc.1210913
134. [134]
  C.B. Rodell, S.P. Arlauckas, M.F. Cuccarese, et al., Nat. Biomed. Eng. 2(2018) 578-588. doi: 10.1038/s41551-018-0236-8
135. [135]
  M. Ovais, M. Guo, C. Chen, Eur. J. Immunol. 49(2019) 534. doi: 10.1002/eji.201847683
136. [136]
  G.M. Lynn, R. Laga, P.A. Darrah, et al., Nat. Biotechnol. 33(2015) 1201-1210. doi: 10.1038/nbt.3371
137. [137]
  D.J. Dowling, ImmunoHorizons 2(2018) 185-197. doi: 10.4049/immunohorizons.1700063
138. [138]
  L. Nuhn, S. de Koker, S. van Lint, et al., Adv. Mater. 30(2018) 1803397. doi: 10.1002/adma.201803397
139. [139]
  D.S. Wilson, S. Hirosue, M.M. Raczy, et al., Nat. Mater. 18(2019) 175-185. doi: 10.1038/s41563-018-0256-5
140. [140]
  S.Y. Kim, S. Kim, J.E. Kim, et al., ACS Nano 13(2019) 12671-12686. doi: 10.1021/acsnano.9b04207
141. [141]
  H.C. Chen, X. Zhan, K.K. Tran, H. Shen, Biomaterials 34(2013) 6464-6472. doi: 10.1016/j.biomaterials.2013.05.016
142. [142]
  S.K. Biswas, L. Gangi, S. Paul, et al., Blood 107(2006) 2112-2122. doi: 10.1182/blood-2005-01-0428
143. [143]
  J.H. Zheng, V.H. Nguyen, S.N. Jiang, et al., Sci. Transl. Med. 9(2017) 10.
144. [144]
  J.W. Graff, A.M. Dickson, G. Clay, A.P. McCaffrey, M.E. Wilson, J. Biol. Chem. 287(2012) 21816-21825. doi: 10.1074/jbc.M111.327031
145. [145]
  N. Wang, H.W. Liang, K. Zen, Front. Immunol. 5(2014) 614.
146. [146]
  Y.Y. Zhang, M.Y. Zhang, M. Zhong, Q.F. Suo, K. Lv, Int. J. Mol. Med. 31(2013) 797-802. doi: 10.3892/ijmm.2013.1260
147. [147]
  Q.Y. Yang, N.N. Guo, Y. Zhou, et al., Acta Pharm. Sin. B 10(2020) 2156-2170. doi: 10.1016/j.apsb.2020.04.004
148. [148]
  A. Pervaiz, M. Zepp, S. Mahmood, et al., Cell. Oncol. 42(2019) 93-106. doi: 10.1007/s13402-018-0415-3
149. [149]
  Y. Ban, J. Mai, X. Li, et al., Cancer Res. 77(2017) 2857-2868. doi: 10.1158/0008-5472.CAN-16-2913
150. [150]
  F. Balkwill, Nat. Rev. Cancer 4(2004) 540-550. doi: 10.1038/nrc1388
151. [151]
  O.R. Colegio, C. Ngoc-Quynh, A.L. Szabo, et al., Nature 513(2014) 559-563. doi: 10.1038/nature13490
152. [152]
  J.W. Pollard, Nat. Rev. Cancer 4(2004) 71-78. doi: 10.1038/nrc1256
153. [153]
  J. Conde, C.C. Bao, Y.Q. Tan, et al., Adv. Funct. Mater. 25(2015) 4183-4194. doi: 10.1002/adfm.201501283
154. [154]
  T. Wang, W. Mu, F. Li, et al., Nanoscale 12(2020) 16851-16863. doi: 10.1039/D0NR04025H
155. [155]
  T. Wu, M. Tan, H.Y. Gong, Y. Wang, X.T. Shuai, Chin. J. Polym. Sci. 36(2018) 1312-1320. doi: 10.1007/s10118-018-2158-z
156. [156]
  Q. Wang, H. Jiang, Y. Li, et al., Biomaterials 122(2017) 10-22. doi: 10.1016/j.biomaterials.2017.01.008
157. [157]
  T. Wu, M. Tan, H.Y. Gong, Y. Wang, X.T. Shuai, Chin. J. Polym. Sci. 36(2018) 1312-1320. doi: 10.1007/s10118-018-2158-z
158. [158]
  E. Lubberts, M.I. Koenders, B. Oppers-Walgreen, et al., Arthritis Rheum. 50(2004) 650-659. doi: 10.1002/art.20001
159. [159]
  Y.H. Yang, L.N. Guo, Z. Wang, et al., Biomaterials 264(2021) 16.
160. [160]
  R.A. Petros, J.M. DeSimone, Nat. Rev. Drug Discov. 9(2010) 615-627. doi: 10.1038/nrd2591
161. [161]
  J. Hu, X. Yuan, F. Wang, et al., Chin. Chem. Lett. 32(2021) 1341-1347. doi: 10.1016/j.cclet.2020.11.006
162. [162]
  S. Konisti, S. Kiriakidis, E.M. Paleolog, Nat. Rev. Rheumatol. 8(2012) 153-162. doi: 10.1038/nrrheum.2011.205
163. [163]
  V.W.M. van Hinsbergh, E.C. Eringa, M. Daemen, Curr. Opin. Lipidol. 26(2015) 405-411. doi: 10.1097/MOL.0000000000000210
164. [164]
  H. Maeda, Y. Matsumura, Crit. Rev. Ther. Drug Carrier Syst. 6(1989) 193-210.
165. [165]
  Y. Matsumura, H. Maeda, Cancer Res. 46(1986) 6387-6392.
166. [166]
  H. Pelicano, D.S. Martin, R.H. Xu, P. Huang, Oncogene 25(2006) 4633-4646. doi: 10.1038/sj.onc.1209597
167. [167]
  M.B. Yatvin, W. Kreutz, B.A. Horwitz, M. Shinitzky, Science 210(1980) 1253-1255. doi: 10.1126/science.7434025
168. [168]
  H.L. Li, J.M. Li, X.Y. He, et al., Chin. Chem. Lett. 30(2019) 1083-1088. doi: 10.1016/j.cclet.2019.01.003
169. [169]
  P. Zheng, Y. Liu, J.J. Chen, et al., Chin. Chem. Lett. 31(2020) 1178-1182. doi: 10.1016/j.cclet.2019.12.001
170. [170]
  Y.A. Lee, J.Y. Kim, S.J. Hong, et al., Clin. Rheumatol. 26(2007) 2023-2029. doi: 10.1007/s10067-007-0605-2
171. [171]
  H.A. Elshabrawy, Z. Chen, M.V. Volin, et al., Angiogenesis 18(2015) 433-448. doi: 10.1007/s10456-015-9477-2
172. [172]
  H.R. Schumacher Jr., Ann. N. Y. Acad. Sci. 256(1975) 39-64. doi: 10.1111/j.1749-6632.1975.tb36034.x
173. [173]
  J. Hwang, K. Rodgers, J.C. Oliver, T. Schluep, Int. J. Nanomed. 3(2008) 359-371.
174. [174]
  J.M. Metselaar, W.B. van den Berg, A.E.M. Holthuysen, et al., Ann. Rheum. Dis. 63(2004) 348-353. doi: 10.1136/ard.2003.009944
175. [175]
  A. Asthana, A.S. Chauhan, P.V. Diwan, N.K. Jain, AAPS PharmSciTech 6(2005) E536-E542. doi: 10.1208/pt060367
176. [176]
  erson R., A. Franch, M. Castell, et al., Arthrit. Res. Ther. 12(2010) R147. doi: 10.1186/ar3089
177. [177]
  L. Quan, Y. Zhang, A. Dusad, et al., Pharm. Res. 33(2016) 186-193. doi: 10.1007/s11095-015-1776-1
178. [178]
  Y. Komano, N. Yagi, I. Onoue, et al., J. Pharmacol. Exp. Ther. 340(2012) 109-113. doi: 10.1124/jpet.111.185884
179. [179]
  J.M. Metselaar, M.H.M. Wauben, J.P.A. Wagenaar-Hilbers, O.C. Boerman, G. Storm, Arthritis Rheum 48(2003) 2059-2066. doi: 10.1002/art.11140
180. [180]
  T. Ishihara, T. Kubota, T. Choi, M. Higaki, J. Pharmacol. Exp. Ther. 329(2009) 412-417. doi: 10.1124/jpet.108.150276
181. [181]
  P. Srinath, M.G. Chary, S.P. Vyas, P.V. Diwan, Pharm. Acta Helv. 74(2000)399-404. doi: 10.1016/S0031-6865(00)00023-6
182. [182]
  S. Palakurthi, S.P. Vyas, P.V. Diwan, Int. J. Pharm. 290(2005) 55-62. doi: 10.1016/j.ijpharm.2004.11.017
183. [183]
  D. Wang, S.C. Miller, X.M. Liu, et al., Arthrit. Res. Ther. 9(2007) R2. doi: 10.1186/ar2106
184. [184]
  S.J. Lee, A. Lee, S.R. Hwang, et al., Mol. Ther. 22(2014) 397-408. doi: 10.1038/mt.2013.245
185. [185]
  J.J. Chiu, S. Chien, Physiol. Rev. 91(2011) 327-387. doi: 10.1152/physrev.00047.2009
186. [186]
  K.J. Moore, I. Tabas, Cell 145(2011) 341-355. doi: 10.1016/j.cell.2011.04.005
187. [187]
  J.A. van Diepen, J.F.P. Berbee, L.M. Havekes, P.C.N. Rensen, Atherosclerosis 228(2013) 306-315. doi: 10.1016/j.atherosclerosis.2013.02.028
188. [188]
  P.R. Moreno, K.R. Purushothaman, M. Sirol, A.P. Levy, V. Fuster, Circulation 113(2006) 2245-2252. doi: 10.1161/CIRCULATIONAHA.105.578955
189. [189]
  P.R. Moreno, J. Sanz, V. Fuster, J. Am. Coll. Cardiol. 53(2009) 2315-2323. doi: 10.1016/j.jacc.2009.02.057
190. [190]
  F.D. Kolodgie, J. Narula, C. Yuan, et al., J. Am. Coll. Cardiol. 49(2007)2093-2101. doi: 10.1016/j.jacc.2006.10.083
191. [191]
  S. Chono, Y. Tauchi, Y. Deguchi, K. Morimoto, J. Drug Targeting 13(2005)267-276. doi: 10.1080/10611860500159030
192. [192]
  M. Ogawa, R. Uchino, A. Kawai, M. Kosugi, Y. Magata, Nucl. Med. Biol. 42(2015) 299-304. doi: 10.1016/j.nucmedbio.2014.12.004
193. [193]
  S.I. Ahn, H.J. Park, J. Yom, T. Kim, Y. Kim, Nano Res 11(2018) 5130-5143. doi: 10.1007/s12274-018-2101-1
194. [194]
  E.A. Fisher, J.E. Feig, B. Hewing, S.L. Hazen, J.D. Smith, Arterioscler. Thromb. V asc. Biol. 32(2012) 2813-2820. doi: 10.1161/ATVBAHA.112.300133
195. [195]
  X. Sun, D. Gao, L. Gao, et al., Theranostics 5(2015) 597-608. doi: 10.7150/thno.11546
196. [196]
  C. Zhang, X. Yu, L. Gao, et al., Theranostics 7(2017) 4276-4288. doi: 10.7150/thno.20999
197. [197]
  Y. Zhao, H. Wang, Y. Yang, et al., Int. J. Nanomedicine 15(2020) 9571-9586. doi: 10.2147/IJN.S275670
198. [198]
  Y. Hattori, S. Kawakami, S. Suzuki, F. Yamashita, M. Hashida, Biochem. Biophys. Res. Commun. 317(2004) 992-999. doi: 10.1016/j.bbrc.2004.03.141
199. [199]
  L.W. Locke, M.W. Mayo, A.D. Yoo, M.B. Williams, S.S. Berr, Biomaterials 33(2012) 7785-7793. doi: 10.1016/j.biomaterials.2012.07.022
200. [200]
  G. Raes, L. Brys, B.K. Dahal, et al., J. Leukoc. Biol. 77(2005) 321-327. doi: 10.1189/jlb.0304212
201. [201]
  M.J. Turk, D.J. Waters, P.S. Low, Cancer Lett. 213(2004) 165-172. doi: 10.1016/j.canlet.2003.12.028
202. [202]
  T. Nagai, M. Tanaka, Y. Tsuneyoshi, et al., Cancer Immunol. Immunother. 58(2009) 1577-1586. doi: 10.1007/s00262-009-0667-x
203. [203]
  K.M. McMahon, M.P. Plebanek, C.S. Thaxton, Adv. Funct. Mater. 26(2016) 7824-7835. doi: 10.1002/adfm.201602600
204. [204]
  J.H. Graversen, P. Svendsen, F. Dagnaes-Hansen, et al., Mol. Ther. 20(2012) 1550-1558. doi: 10.1038/mt.2012.103
1. [1]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
2. [2]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
3. [3]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
4. [4]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
5. [5]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
6. [6]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
7. [7]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
8. [8]
  Keke Han , Wenjun Rao , Xiuli You , Haina Zhang , Xing Ye , Zhenhong Wei , Hu Cai . Two new high-temperature molecular ferroelectrics [1,5-3.2.2-Hdabcni]X (X = ClO₄⁻, ReO₄⁻). Chinese Chemical Letters, 2024, 35(6): 108809-. doi: 10.1016/j.cclet.2023.108809
9. [9]
  Chenlu Huang , Xinyu Yang , Qingyu Yu , Linhua Zhang , Dunwan Zhu . Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680-. doi: 10.1016/j.cclet.2024.109680
10. [10]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
11. [11]
  Xinyue Lan , Junguang Liang , Churan Wen , Xiaolong Quan , Huimin Lin , Qinqin Xu , Peixian Chen , Guangyu Yao , Dan Zhou , Meng Yu . Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy. Chinese Chemical Letters, 2024, 35(4): 108616-. doi: 10.1016/j.cclet.2023.108616
12. [12]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
13. [13]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
14. [14]
  Yixin Zhang , Ting Wang , Jixiang Zhang , Pengyu Lu , Neng Shi , Liqiang Zhang , Weiran Zhu , Nongyue He . Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chinese Chemical Letters, 2024, 35(4): 108619-. doi: 10.1016/j.cclet.2023.108619
15. [15]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
16. [16]
  Fereshte Hassanzadeh-Afruzi , Mina Azizi , Iman Zare , Ehsan Nazarzadeh Zare , Anwarul Hasan , Siavash Iravani , Pooyan Makvandi , Yi Xu . Advanced metal-organic frameworks-polymer platforms for accelerated dermal wound healing. Chinese Chemical Letters, 2024, 35(11): 109564-. doi: 10.1016/j.cclet.2024.109564
17. [17]
  Shenglan Zhou , Haijian Li , Hongyi Gao , Ang Li , Tian Li , Shanshan Cheng , Jingjing Wang , Jitti Kasemchainan , Jianhua Yi , Fengqi Zhao , Wengang Qu . Recent advances in metal-loaded MOFs photocatalysts: From single atom, cluster to nanoparticle. Chinese Chemical Letters, 2025, 36(1): 110142-. doi: 10.1016/j.cclet.2024.110142
18. [18]
  Jiahao Liu , Peng Liu , Junhong Duan , Qiongxuan Xie , Jie Feng , Hongpei Tan , Ze Mi , Ying Li , Yunjie Liao , Pengfei Rong , Wenhu Zhou , Xiang Gao . Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy. Chinese Chemical Letters, 2024, 35(12): 109632-. doi: 10.1016/j.cclet.2024.109632
19. [19]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
20. [20]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113

Get Citation

PDF

XML

Metrics

PDF Downloads(14)
Abstract views(1920)
HTML views(85)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142