Citation: Juanjuan Li, Hongjie Luo, Xueqiong Zhu, Jianfu Zhao, Tianfeng Chen. Designing DNA cage-based immuno-fluorescence strategy for rapid diagnosis of clinical cervical cancer tissues[J]. Chinese Chemical Letters, ;2022, 33(2): 788-792. doi: 10.1016/j.cclet.2021.08.088 shu

Designing DNA cage-based immuno-fluorescence strategy for rapid diagnosis of clinical cervical cancer tissues

Juanjuan Li ^a ,
Hongjie Luo ^a ,
Xueqiong Zhu ^b ,
Jianfu Zhao ^{a, *,} ,
Tianfeng Chen ^{a, *,}

a.
Department of Oncology, The First Affiliated Hospital, and Department of Chemistry, Jinan University, Guangzhou 510632, China
b.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China

zhaojianfu@jnu.edu.cn

tchentf@jnu.edu.cn

Received Date: 15 April 2021
Revised Date: 10 August 2021
Accepted Date: 18 August 2021
Available Online: 22 August 2021

Figures(5)

Exploiting a tissue diagnosis method to abstain the involuted operating and consume valuable reagents while realizing high-speed and inexpensive pathological grading technology to supply a better scheme for cancer therapy is a significant method of cancers detection. A promising immuno-fluorescence strategy was rationally designed and synthesized by loading ruthenium complex into cervical cancer-targeted DNA-cage, which was well used to realize high-speed and inexpensive diagnosis of clinical cervical cancer tumor tissues avoiding the traditional multi-stage process, thus demonstrating high application potential in clinical pathological grading and surgical judgment. Moreover, it has been finding that Apts-DNA@Ru can enrichment in the tumor region, interestingly, no enrichment in normal cervical cancer tissue. It has the potential to realize the integration of in vivo diagnose and further synchronous treatment in the near future. Thence, this study demonstrates a strategy for integration of cancer-targeted DNA-cage and fluorescent RuPOP as alternative IHC reagents for next-generation more rapid convenient cancer detection.
- Rapid diagnostic,
- Pathological grading,
- Cervical cancer,
- Immuno-fluorescence,
- Cancer-targeted DNA-cage
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