Citation: Chaoqun Wang, Ziqiang Deng, Hu Zhang, Rui Liu, Yi Lv. Old commercialized magnetic particles new trick: Intrinsic internal standard[J]. Chinese Chemical Letters, ;2022, 33(3): 1267-1270. doi: 10.1016/j.cclet.2021.07.049 shu

Old commercialized magnetic particles new trick: Intrinsic internal standard

Chaoqun Wang ^a ,
Ziqiang Deng ^b ,
Hu Zhang ^c ,
Rui Liu ^{b, *,} ,
Yi Lv ^a

a.
Analytical & Testing Center, Sichuan University, Chengdu 610064, China
b.
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
c.
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China

liur@scu.edu.cn

Received Date: 12 May 2021
Revised Date: 1 July 2021
Accepted Date: 21 July 2021
Available Online: 29 July 2021

Figures(3)

Magnetic particles (MPs) are the most widely used commercialized engineering particles, which gained great success in various biological applications. Inspired by their intrinsic Fe isotope composition, we discovered a commercialized MPs-internal standard's novel function to realize the accurate quantification of biomolecules. The bioassay of carcinoembryonic antigen (CEA) was chosen as a modal system. The Fe isotope in MPs and Au isotope in report probes were simultaneously and sensitively detected by the elemental mass spectrometry. ¹⁹⁷Au/⁵⁷Fe isotopic ratios and CEA concentrations showed good linearity in the range of 0.6–300 ng/mL, with a detection limit of 0.09 ng/mL (3σ). The accuracy and precision of the proposed MPs-based immunoassay were greatly improved, by eliminating potential MPs loss during magnetic separation and absolute intensity fluctuations. Considering the exceptional availability and universality of commercialized MPs, the proposed method might open a new avenue for MPs' biological applications.
- Magnetic particles,
- Ratiometric,
- Immunoassay,
- ICPMS,
- Carcinoembryonic antigen
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