Citation: Xiaolei Zhu, Yangen Huang, Xiuhua Xu, Fengling Qing. Iron-catalyzed cyanoalkylation of difluoroenol silyl ethers with cyclobutanone oxime esters[J]. Chinese Chemical Letters, ;2022, 33(2): 817-820. doi: 10.1016/j.cclet.2021.07.030 shu

Iron-catalyzed cyanoalkylation of difluoroenol silyl ethers with cyclobutanone oxime esters

Xiaolei Zhu ^a ,
Yangen Huang ^a ,
Xiuhua Xu ^{b, *} ,
Fengling Qing ^{a, b, *}

a.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
b.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Science, Chinese Academy of Science, Shanghai 200032, China

xuxiuhua@sioc.ac.cn

flq@mail.sioc.ac.cn

Received Date: 5 May 2021
Revised Date: 6 July 2021
Accepted Date: 30 July 2021
Available Online: 5 August 2021

Figures(6)

An iron-catalyzed coupling reaction of difluoroenol silyl ethers and cyclobutanone oxime esters is described. This protocol provides a convenient access to various previously unknown and potentially useful gem-difluoromethylenated ketonitriles inmoderate to good yields. The transformations of resulting products to other fluorinecontaining products is also documented.
- Cyanoalkylation,
- Difluoroenol silyl ether,
- Cyclobutanone oxime ester,
- Iron catalysis,
- Radical reaction
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