Citation: Xinxin Liu, Cuixia Zheng, Yueyue Kong, Hao Wang, Lei Wang. An in situ nanoparticle recombinant strategy for the enhancement of photothermal therapy[J]. Chinese Chemical Letters, ;2022, 33(1): 328-333. doi: 10.1016/j.cclet.2021.07.025 shu

An in situ nanoparticle recombinant strategy for the enhancement of photothermal therapy

Xinxin Liu ^{a, b, c, d, e} ,
Cuixia Zheng ^{b, c, d} ,
Yueyue Kong ^{b, c, d} ,
Hao Wang ^{b, c, d} ,
Lei Wang ^{a, b, c, d, e, *,}

a.
Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 471009, China
b.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
c.
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
d.
Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China
e.
Tumor Immunity and Biomaterials Advanced Medical Center, Zhengzhou University, Luoyang 471009, China

wanglei1@zzu.edu.cn

Received Date: 17 May 2021
Revised Date: 2 July 2021
Accepted Date: 7 July 2021
Available Online: 14 July 2021

Figures(5)

Photothermal therapy (PTT)-induced immune response has attracted much attention, however, which cannot work at full capacity. In this study, the simvastatin (SV) adjuvant is loaded into gold nanocages (AuNCs) to develop a simple drug delivery system, which can efficiently utilize the tumor-associated antigens (TAAs) for improving immune responses. AuNCs/SV-mediated PTT treatment enhances tumor cells damage and promotes the release of TAAs which are immediately captured by AuNCs/SV to form AuNCs/SV/TAAs recombinant nanoparticle. Impressively, AuNCs/SV/TAAs can accumulate in lymph nodes effectively due to the suitable size of ~55 nm and hyperthermia-induced vasodilative effect. And the co-delivery of antigen and adjuvant is beneficial to stimulating the maturation of dendritic cells for further activating T cells. In a word, the recombinant strategy could make full use of TAAs to produce an individual powerful immunotherapy.
- Photothermal therapy,
- Tumor-associated antigens,
- Recombinant nanoparticle,
- T cells activation,
- Individual immunotherapy
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