Citation: Yamin Liu, Siyang Jiang, Weipeng Mao, Pintao Li, Fang Zhou, Da Ma. Smart supramolecular vesicles based on glutathione-reactive pillar[6]arene and acid-labile prodrug: Dual drug loading and sequential release[J]. Chinese Chemical Letters, ;2022, 33(1): 209-212. doi: 10.1016/j.cclet.2021.07.024 shu

Smart supramolecular vesicles based on glutathione-reactive pillar[6]arene and acid-labile prodrug: Dual drug loading and sequential release

Yamin Liu ^b ,
Siyang Jiang ^b ,
Weipeng Mao ^b ,
Pintao Li ^b ,
Fang Zhou ^b ,
Da Ma ^{a, b, *,}

a.
College of Chemistry, and Green Catalysis Center, Zhengzhou University, Zhengzhou 450001, China
b.
Department of Chemistry, Fudan University, Shanghai 200433, China

dama@fudan.edu.cn

Received Date: 21 April 2021
Revised Date: 5 July 2021
Accepted Date: 8 July 2021
Available Online: 14 July 2021

Figures(6)

Glutathione thiol-reactive pillar[6]arene (TWP6) is designed and synthesized as the first example of reducing agent-reactive host molecule. TWP6 shows high affinity binding towards suitable anti-tumor drugs and guests. Doxorubicin-based acid-labile prodrugs and TWP6 are used to construct supramolecular vesicles, which are also loaded with camptothecin. The supramolecular vesicles loaded with two drugs demonstrate glutathione- and acid-responsive drug release as well as sequential release to both stimuli types. Supramolecular vesicles show combination therapeutic effect towards tumor cells in vitro.
- Host-guest systems,
- Pillararene,
- Self-assembly,
- Redox responsive,
- Drug delivery
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