Citation: Yanyan Wang, Dongxiang Zhang, Kangming Xiong, Rong Shang, Xin-Dong Jiang. Near-infrared absorbing (>700 nm) aza-BODIPYs by freezing the rotation of the aryl groups[J]. Chinese Chemical Letters, ;2022, 33(1): 115-122. doi: 10.1016/j.cclet.2021.06.083 shu

Near-infrared absorbing (>700 nm) aza-BODIPYs by freezing the rotation of the aryl groups

Yanyan Wang ^{a, 1} ,
Dongxiang Zhang ^{a, 1} ,
Kangming Xiong ^b ,
Rong Shang ^c ,
Xin-Dong Jiang ^{a, *,}

a.
Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang 110142, China
b.
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
c.
Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 7398526, Japan

xdjiang@syuct.edu.cn

Received Date: 21 April 2021
Revised Date: 10 June 2021
Accepted Date: 28 June 2021
Available Online: 5 July 2021

Figures(20)

The typical aza-BODIPYs in the dye family are known for bright fluorescence, excellent stability, and tunable absorption wavelengths. Hence, these dyes are attracting the increasing attention. Aza-BODIPYs having the maxima absorption in the near-infrared (NIR) region (650–900 nm) are very favorable for bioimaging in vivo due to the less photo-damage, deeper tissue penetration, and less interference from background auto-fluorescence by biomolecules in the living systems. Many strategies have been employed to modify the structures of the aza-BODIPY core to provide the NIR absorbing dyes. Among these, the most effective method is the fusion of the aromatic rings in aza-BODIPY system. This review allsidedly summarizes the recent development of ring-fused aza-BODIPY dyes (λ_abs > 700 nm) focusing on the design, synthesis, and potential applications in the NIR region since 2002.
- Aza-BODIPY,
- NIR,
- Ring-fused,
- Red shift,
- Freezing rotation
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