Citation: Yang Wang, Qing Li, Mengsheng Deng, Kuijun Chen, Jianmin Wang. Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy[J]. Chinese Chemical Letters, ;2022, 33(1): 324-327. doi: 10.1016/j.cclet.2021.06.080 shu

Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy

Yang Wang ^{a, b, 1,} ,
Qing Li ^{a, 1} ,
Mengsheng Deng ^a ,
Kuijun Chen ^a ,
Jianmin Wang ^{a, *,}

a.
State Key Laboratory of Trauma, Burns and Combined Injury, Department of Surgical Research, Daping Hospital, Army Medical University, Chongqing 400042, China
b.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

wangyzu@126.com

jmwang@tmmu.edu.cn

Received Date: 16 March 2021
Revised Date: 25 June 2021
Accepted Date: 28 June 2021
Available Online: 3 July 2021

Figures(4)

Metal-organic frameworks (MOFs) have recently allured a variety of concern in the fields of nanotechnology. However, exploring their biomedical applications is still a relatively new field. In this work, zeolite imidazole skeleton-8 (ZIF-8) was reported for the first time as a drug carrier for the treatment of lung injury. Uniform ZIF-8 nanoparticles encapsulating plumbagin (PLB) are achieved by a facile physical adsorption process. Scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and UV–vis absorption spectrum were conducted to investigate the physical properties of ZIF-8 and PLB@ZIF-8. In animal model, the collagen fibers deposition produced by severe lung injury is significantly decreased. The secretion of inflammatory factor TGF-β and IL-6 were efficiently dropped by the combination of plumbagin and ZIF-8. At the same time, the expressions of collagen I, α-SMA and TNF-α were also suppressed. This strategy puts forth a promising blueprint in the application of MOF materials, especially in biomedical fields.
- ZIF-8,
- Plumbagin,
- Drug delivery,
- Lung injury
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