Citation: Yunpeng Sun, Letian Cui, Qiurong Li, Pengfei Tang, Yongyi Li, Wenjun Xu, Jun Luo, Lingyi Kong. Mufolinin A, an unprecedented ring A-seco 10-ethyllimonoid from Munronia unifoliolata[J]. Chinese Chemical Letters, ;2022, 33(1): 516-518. doi: 10.1016/j.cclet.2021.06.050 shu

Mufolinin A, an unprecedented ring A-seco 10-ethyllimonoid from Munronia unifoliolata

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China

luojun@cpu.edu.cn

cpu_lykong@126.com

Received Date: 8 May 2021
Revised Date: 8 June 2021
Accepted Date: 18 June 2021
Available Online: 25 June 2021

Figures(3)

Mufolinin A (1), a ring A-seco rearranged limonoid with an unprecedented ethyl at C-10 and novel 6/6/6/5 fused-ring skeleton, together with three new potential precursors (ring A-seco limonoids, 2–4) were isolated from Munronia unifoliolata. Their structures and absolute configurations were confirmed by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), X-ray crystallography, electronic circular dichroism (ECD) calculations and NMR calculations with DP4+ analyses. The unprecedented ethyl group of 1 was hypothesized to be derived from methyl migration and ring reduction rearrangement of ring A-seco limonoid 4. Compounds 2 and 4 showed significant multidrug resistance (MDR) reversal activities in MCF-7/DOX cells with reversal fold (RF) values of 13.1 and 8.0, respectively.
- Meliaceae,
- Munronia unifoliolata,
- Limonoids,
- Anti-inflammatory,
- Anti-multidrug resistance
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沈阳化工大学材料科学与工程学院沈阳 110142