Citation: Shuang Chen, Yongzhuo Liu, Ri Liang, Gaobo Hong, Jing An, Xiaojun Peng, Wen-Heng Zheng, Fengling Song. Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy[J]. Chinese Chemical Letters, ;2021, 32(12): 3903-3906. doi: 10.1016/j.cclet.2021.06.041 shu

Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy

Shuang Chen ^a ,
Yongzhuo Liu ^b ,
Ri Liang ^a ,
Gaobo Hong ^a ,
Jing An ^a ,
Xiaojun Peng ^a ,
Wen-Heng Zheng ^{c, *} ,
Fengling Song ^{a, d, *}

a.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
b.
Shandong Collaborative Innovation Center of Eco-Chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
c.
Department of Medical Imaging, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, China
d.
Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China

Mir2yue2@163.com

songfl@dlut.edu.cn

songfl@sdu.edu.cn

Received Date: 5 May 2021
Revised Date: 11 June 2021
Accepted Date: 15 June 2021
Available Online: 21 June 2021

Figures(5)

A variety of nano-engineered photosensitizers have been developed for photodynamic therapy (PDT) of cancer diseases. However, traditional nano-engineering methods usually cannot avoid drug leakage and premature release, and have disadvantages such as low drug load and inaccurate release. The self-assembly strategy based on amphiphilic peptides has been considered to be more attractive nano-engineering method. Here we developed novel acid-activatable self-assembled nanophotosensitizers based on an amphiphilic peptide derivative. The peptide derivative was synthesized from a fluorescein molecule with thermally activated delayed fluorescence (TADF). The self-assembled nanophotosensitizers can specifically enter the tumor cells and disassemble inside lysosomes companied with "turn-on" fluorescence and photodynamic therapy effect. Such smart nanophotosensitizers will open new opportunities for cancer theranostics.
- Photodynamic therapy,
- Nanophotosensitizer,
- Peptides,
- Self-assembly,
- Acid-activatable
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