Citation: Han Wang, Yongbin Xie, Yicheng Zhou, Nannan Cen, Wenbo Chen. Catalyst-free, direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF₃ source[J]. Chinese Chemical Letters, ;2022, 33(1): 221-224. doi: 10.1016/j.cclet.2021.06.008 shu

Catalyst-free, direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF₃ source

Han Wang ^a ,
Yongbin Xie ^a ,
Yicheng Zhou ^a ,
Nannan Cen ^a ,
Wenbo Chen ^{a, b, *,}

a.
Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China
b.
CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

wenbochen@shiep.edu.cn

Received Date: 1 April 2021
Revised Date: 3 June 2021
Accepted Date: 3 June 2021
Available Online: 10 June 2021

Figures(6)

A new electrochemical strategy for trifluoromethylation/cyclization using TfNHNHBoc as a CF₃ source was established. This approach was realized by the direct electrolysis of TfNHNHBoc under external oxidant-free and catalyst-free conditions, and afforded various trifluoromethylated oxindoles with good functional group compatibility and broad substrate scope. Preliminary mechanistic studies show that the reaction proceeds by a radical process.
- Electrolysis,
- Trifluoromethylation,
- Cyclization,
- TfNHNHBoc,
- Radical process
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Catalyst-free, direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF3 source

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通讯作者: 陈斌, bchen63@163.com

Catalyst-free, direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF₃ source