Citation: Jiangyan Tian, Wendian Li, Ruihao Li, Lin He, Hui Lv. Nickel-catalyzed asymmetric arylative cyclization of N-alkynones: Efficient access to 1, 2, 3, 6-tetrahydropyridines with a tertiary alcohol[J]. Chinese Chemical Letters, ;2021, 32(12): 4038-4040. doi: 10.1016/j.cclet.2021.06.006 shu

Nickel-catalyzed asymmetric arylative cyclization of N-alkynones: Efficient access to 1, 2, 3, 6-tetrahydropyridines with a tertiary alcohol

Jiangyan Tian ^a ,
Wendian Li ^a ,
Ruihao Li ^a ,
Lin He ^b ,
Hui Lv ^{a, b, *,}

a.
key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, Sauvage Center for Molecular Sciences, Wuhan University, Wuhan 430072, China
b.
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000, China

huilv@whu.edu.cn

Received Date: 21 March 2021
Revised Date: 3 June 2021
Accepted Date: 3 June 2021
Available Online: 12 June 2021

Figures(3)

Nickel/(S)-t-Bu-PHOX complex catalyzed asymmetric arylative cyclization of N-alkynones has been achieved, delivering 1, 2, 3, 6-tetrahydropyridines containing a chiral tertiary alcohol in high yields and excellent enantioselectivities, which provides efficient access to chiral tetrahydropyridine and piperidine analogues.
- Asymmetric catalysis,
- Alkynones,
- Cyclization,
- Nickel
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