Citation: Difeng Yin, Yucen Li, Lingling Xia, Wenbo Li, Wei Chu, Jianping Yu, Miao Wu, Ya Cheng, Ming Hu. Automated synthesis of gadopentetate dimeglumine through solid-liquid reaction in femtosecond laser fabricated microfluidic chips[J]. Chinese Chemical Letters, ;2022, 33(2): 1077-1080. doi: 10.1016/j.cclet.2021.05.073 shu

Automated synthesis of gadopentetate dimeglumine through solid-liquid reaction in femtosecond laser fabricated microfluidic chips

Difeng Yin ^{a, b} ,
Yucen Li ^c ,
Lingling Xia ^c ,
Wenbo Li ^{a, b, d} ,
Wei Chu ^{e, *,} ,
Jianping Yu ^{a, b} ,
Miao Wu ^c ,
Ya Cheng ^{a, d, e, *,} ,
Ming Hu ^{c, *,}

a.
State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-intense Laser Science, Shanghai Institute of Optics and Fine Mechanics (SIOM), Chinese Academy of Sciences (CAS), Shanghai 201800, China
b.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
c.
State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China
d.
School of Physical Science and Technology, ShanghaiTech University, Shanghai 200031, China
e.
XXL - The Extreme Optoelectromechanics Laboratory, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China

wchu@phy.ecnu.edu.cn

ya.cheng@siom.ac.cn

mhu@phy.ecnu.edu.cn

Received Date: 13 May 2021
Revised Date: 27 May 2021
Accepted Date: 31 May 2021
Available Online: 4 June 2021

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Despite the continuously increased requirement on automated synthesis of medicines for distributed manufacturing and personal care, it remains a challenge to realize automated synthesis which requires solid-liquid phase reactions. In this work, we demonstrated an automated solid-liquid synthesis for gadopentetate dimeglumine, the most widely used magnetic resonance imaging (MRI) contrast agent. The high-efficiency reaction was performed in a 3D microfluidic chip which was fabricated by femtosecond laser micromachining. The structure of the chip realized 3D shear flow which was essential for highly efficient mixing and movement of the solid-liquid mixtures. Ultraviolet visible (UV-vis) spectrometer was employed for in-line analysis to help automation of this system. Comparing with the round-bottom flask system, this synthetic system showed significantly higher reaction rate, indicating the advantage of the 3D microfluidic technology in micro chemical engineering.
- Automated synthesis,
- Femtosecond laser micromachining,
- Microfluidics,
- MRI imaging,
- UV-vis absorption spectrum
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