Citation: Xiao-Yu Zhou, Xiang-Yu Li, Zhen Zhang, Da-Gang Yu. Thiocarbonylation of C(sp³)-H bonds in pyridylamines with CS₂: Facile synthesis of pyrido[1,2-a]pyrimidine-4-thiones[J]. Chinese Chemical Letters, ;2021, 32(12): 4015-4018. doi: 10.1016/j.cclet.2021.05.055 shu

Thiocarbonylation of C(sp³)-H bonds in pyridylamines with CS₂: Facile synthesis of pyrido[1,2-a]pyrimidine-4-thiones

Xiao-Yu Zhou ^a ,
Xiang-Yu Li ^a ,
Zhen Zhang ^{a, b, *,} ,
Da-Gang Yu ^{a, *,}

a.
Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
b.
Key laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China

zhangzhen1@cdu.edu.cn

dgyu@scu.edu.cn

Received Date: 28 March 2021
Revised Date: 24 May 2021
Accepted Date: 24 May 2021
Available Online: 29 May 2021

Figures(5)

Herein, a facile synthesis of valuable pyrido[1,2-a]pyrimidine-4-thiones is reported via novel thiocarbonylation of C(sp³)-H bonds with carbon disulfide (CS₂). This reaction features easy availability of substrates, good functional group tolerance, high yields, facile scalability and atom economy. Mechanistic investigations indicate that sulfate anion and sulfuric anhydride anion might be involved in this reaction.
- Pyridinylamines,
- Thiocarbonylation,
- Pyrido[1,2-a]pyrimidine-4-thiones,
- Carbon disulfide,
- Ketoimines
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Thiocarbonylation of C(sp3)-H bonds in pyridylamines with CS2: Facile synthesis of pyrido[1,2-a]pyrimidine-4-thiones

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通讯作者: 陈斌, bchen63@163.com

Thiocarbonylation of C(sp³)-H bonds in pyridylamines with CS₂: Facile synthesis of pyrido[1,2-a]pyrimidine-4-thiones