Citation: Zengjin Liu, Ying Zheng, Ting Xie, Zihan Chen, Zhenlong Huang, Zhiwei Ye, Yi Xiao. Clickable rhodamine spirolactam based spontaneously blinking probe for super-resolution imaging[J]. Chinese Chemical Letters, ;2021, 32(12): 3862-3864. doi: 10.1016/j.cclet.2021.04.038 shu

Clickable rhodamine spirolactam based spontaneously blinking probe for super-resolution imaging

Zengjin Liu ^{a, 1*,} ,
Ying Zheng ^{b, 1} ,
Ting Xie ^a ,
Zihan Chen ^a ,
Zhenlong Huang ^{a, b} ,
Zhiwei Ye ^{b, *,} ,
Yi Xiao ^{b, *,}

a.
Drug Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, China
b.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

zengjinliu@swmu.edu.cn

yezhiwei@dlut.edu.cn

xiaoyi@dlut.edu.cn

Received Date: 5 February 2021
Revised Date: 6 April 2021
Accepted Date: 18 April 2021
Available Online: 27 April 2021

Figures(4)

Spontaneously blinking probe, which switches between dark and bright state without UV or external additives, is extremely attractive in super resolution imaging of live cells. Herein, a clickable rhodamine spirolactam probe, Atto565-Tet, is rationally constructed for spontaneously blinking after biorthogonal labelling and successfully applied to super resolution imaging of mitochondria and lysosomes.
- Super resolution imaging,
- Spontaneously blinking,
- pK_a,
- Rhodamine spirolactam
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