Citation: Qing Yu, Yunyun Liu, Jie-Ping Wan. Metal-free C(sp²)-H perfluoroalkylsulfonylation and configuration inversion: Stereoselective synthesis of α-perfluoroalkylsulfonyl E-enaminones[J]. Chinese Chemical Letters, ;2021, 32(11): 3514-3517. doi: 10.1016/j.cclet.2021.04.037 shu

Metal-free C(sp²)-H perfluoroalkylsulfonylation and configuration inversion: Stereoselective synthesis of α-perfluoroalkylsulfonyl E-enaminones

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China

wanjieping@jxnu.edu.cn

Received Date: 2 March 2021
Revised Date: 13 April 2021
Accepted Date: 18 April 2021
Available Online: 28 April 2021

Figures(5)

The perfluoroalkylsulfonylation (CF₃SO₂, C₂F₅SO₂ and CHF₂SO₂) in the enaminone CH bonds has been developed simply via the promotion of molecular iodine by using stable and cheap sodium perfluoroalkyl sulfinates as coupling partners. The stereoselective synthesis of E-configurated α-perfluoroalkylsulfonyl enaminones has been realized via unprecedented CH bond elaboration and CC double bond configuration inversion by free radical process.
- C–H Functionalization,
- Enaminone,
- Perfluoroalkyl sulfonylation,
- Metal-free,
- Configuration inversion
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Metal-free C(sp2)-H perfluoroalkylsulfonylation and configuration inversion: Stereoselective synthesis of α-perfluoroalkylsulfonyl E-enaminones

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通讯作者: 陈斌, bchen63@163.com

Metal-free C(sp²)-H perfluoroalkylsulfonylation and configuration inversion: Stereoselective synthesis of α-perfluoroalkylsulfonyl E-enaminones