Citation: Yuqi Chen, Mengna Jiang, Liwei Xiong, Xianxian Yao, Mingjian Fan, Danyang Chen, Qi Jiang, Zhaokui Jin, Qianjun He. Novel photo-theranostic GdB₆ nanoparticles for fluorescence imaging and NIR-photothermal therapy[J]. Chinese Chemical Letters, ;2021, 32(11): 3487-3490. doi: 10.1016/j.cclet.2021.04.036 shu

Novel photo-theranostic GdB₆ nanoparticles for fluorescence imaging and NIR-photothermal therapy

Yuqi Chen ^a ,
Mengna Jiang ^a ,
Liwei Xiong ^b ,
Xianxian Yao ^a ,
Mingjian Fan ^a ,
Danyang Chen ^a ,
Qi Jiang ^a ,
Zhaokui Jin ^a ,
Qianjun He ^{a, *,}

a.
Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Marshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China
b.
Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology, Wuhan 430205, China

nanoflower@126.com

Received Date: 12 January 2021
Revised Date: 6 April 2021
Accepted Date: 18 April 2021
Available Online: 24 April 2021

Figures(4)

The development of multifunctional theranostic nano-agents is an important resolution for personalized treatment of cancer. In this work, we synthesized a new kind of gadolinium boride nanoparticles (GBN) by a microwave-assisted chemical etching method, and discovered their optical characteristics including fluorescence imaging and near-infrared (NIR) photothermal conversion capability. Bright greenishyellow fluorescence enabled for intracellular localization, while effective NIR-photothermal conversion supported photothermal therapy (PTT). In vitro and in vivo results indicated that GBN exhibited a superior antitumor performance and high biocompatibility. This study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment.
- Gadolinium boride,
- Nanomedicine,
- Photothermal therapy,
- Fluorescence imaging,
- Theranostics
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Novel photo-theranostic GdB6 nanoparticles for fluorescence imaging and NIR-photothermal therapy

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通讯作者: 陈斌, bchen63@163.com

Novel photo-theranostic GdB₆ nanoparticles for fluorescence imaging and NIR-photothermal therapy