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Citation: Ningbo Li, Shitang Xu, Xueyan Wang, Li Xu, Jie Qiao, Zhiwu Liang, Xinhua Xu. Ag2CO3-catalyzed efficient synthesis of internal or terminal propargylicamines and chalcones via A3-coupling under solvent-free condition[J]. Chinese Chemical Letters, ;2021, 32(12): 3993-3997. doi: 10.1016/j.cclet.2021.04.026 shu

Ag2CO3-catalyzed efficient synthesis of internal or terminal propargylicamines and chalcones via A3-coupling under solvent-free condition

  • a.

    Basic Medical College, Shanxi Medical University, Taiyuan 030001, China

  • b.

    College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

  • c.

    Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China

    * Corresponding author.
    E-mail address: xhx1581@hnu.edu.cn (X. Xu).
    1 These authors contributed equally to this work.
  • Received Date: 23 February 2021
    Revised Date: 14 April 2021
    Accepted Date: 14 April 2021
    Available Online: 20 April 2021

Figures(6)

  • Several simple, fast and practical protocols have been developed to synthesize internal or terminal propargylamines and chalcones via A3-coupling reaction of aldehydes, amines, and alkynes catalyzed by an easily available catalyst Ag2CO3 under solvent-free condition. The reaction proceeded smoothly to deliver various products in good-to-excellent yields with good functional group tolerance. Gram-scale preparation, bioactive molecule synthesis and asymmetric substrates have been demonstrated. Furthermore, plausible mechanisms for the synthesis of different products have been proposed.
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