Citation: Ronghua Jin, Zhongning Liu, Tao Liu, Pingyun Yuan, Yongkang Bai, Xin Chen. Redox-responsive micelles integrating catalytic nanomedicine and selective chemotherapy for effective tumor treatment[J]. Chinese Chemical Letters, ;2021, 32(10): 3076-3082. doi: 10.1016/j.cclet.2021.03.084 shu

Redox-responsive micelles integrating catalytic nanomedicine and selective chemotherapy for effective tumor treatment

Ronghua Jin ^{a, c} ,
Zhongning Liu ^b ,
Tao Liu ^a ,
Pingyun Yuan ^a ,
Yongkang Bai ^a ,
Xin Chen ^{a, *,}

a.
School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, Xi'an Jiao Tong University, Xi'an 710049, China
b.
Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
c.
Pharmaceutical College, Guangxi Medical University, Nanning 530021, China

chenx2015@xjtu.edu.cn

Received Date: 23 January 2021
Revised Date: 31 March 2021
Accepted Date: 1 April 2021
Available Online: 2 April 2021

Figures(5)

Chemotherapy is one of the most conventional modalities for cancer therapy. However, the high multidrug resistance of tumor cells still limited the clinical application of current chemotherapy. Considering the ability of nitric oxide (NO) to modulate potent P-glycoprotein to inhibit multi-drug resistance, a synergistic methodology combining chemotherapy and sustained NO generation is an ideal way to further promote the chemotherapy. Herein, a multi-functional micelle with tumor-selective chemotherapy driven by redox-triggered doxorubicin (DOX) release and drug resistance inhibition based on intracellular NO generation was fabricated for effective tumor treatment. The micelle consists of DOX as core, arginine/glucose oxidase (Arg/GOx) as shell and redox-responsive disulfide bond as a linker, which is denoted as micelle-DOX-Arg-GOx. The Arg serves as the biological precursor of nitric oxide for inhibition of multi-drug resistance to promote chemotherapy and GOx catalyzes glucose to produce hydrogen peroxide (H₂O₂) for increasing the generation of NO. Moreover, the glucose supply could be simultaneously blocked by the catalytic process, which further enhanced therapeutic efficiency. This micelle requests a tumor-specific microenvironment (a considerable amount of GSH) to perform synergistic therapeutics including chemotherapy, starvation therapy (catalytic medicine), and gas therapy for tumor treatment, which resulted in significant cytotoxicity to tumor tissue.
- Chemotherapy,
- Gas therapy,
- Starvation therapy,
- Carrier-free,
- Tumor treatment
1. [1]
  X. Ding, F. Zhu, S. Gao, Food Chem. 131 (2012) 677-684 doi: 10.1016/j.foodchem.2011.09.060
2. [2]
  J. Zhou, G. Yu, F. Huang, Chem. Soc. Rev. 46 (2017) 7021-7053 doi: 10.1039/C6CS00898D
3. [3]
  J. Wen, K. Yang, F. Liu, et al., Chem. Soc. Rev. 46 (2017) 6024-6045 doi: 10.1039/C7CS00219J
4. [4]
  V.P. Torchilin, Nat. Rev. Drug. Discov. 13 (2014) 813-827 doi: 10.1038/nrd4333
5. [5]
  R. Jin, J. Xie, X. Yang, et al., Biomater. Sci. 8 (2020) 1865-1874 doi: 10.1039/c9bm01992h
6. [6]
  Y. Lu, A.A. Aimetti, R. Langer, Z. Gu, Nat. Rev. Mater. 2 (2016) 16075
7. [7]
  Y. Cui, R. Deng, X. Li, et al., Chin. Chem. Lett. 30 (2019) 2291-2294 doi: 10.1016/j.cclet.2019.08.017
8. [8]
  L. Kong, Q. Chen, F. Campbell, et al., Adv. Healthc. Mater. 9 (2020) e1901489 doi: 10.1002/adhm.201901489
9. [9]
  R. Jin, Z. Liu, Y. Bai, et al., ACS Omega 3 (2018) 4306-4315 doi: 10.1021/acsomega.8b00427
10. [10]
  R. Jin, Z. Liu, Y. Bai, et al., Adv. Funct. Mater. 28 (2018) 1801961 doi: 10.1002/adfm.201801961
11. [11]
  R. Jin, Z. Liu, Y. Bai, et al., ACS Appl. Nano Mater. 1 (2018) 302-309 doi: 10.1021/acsanm.7b00152
12. [12]
  R. Cao, W. Sun, Z. Zhang, et al., Chin. Chem. Lett. 31 (2020) 3127-3130 doi: 10.1016/j.cclet.2020.06.031
13. [13]
  A. Zhang, L. Hai, T. Wang, et al., Chin. Chem. Lett. 31 (2020) 3158-3162 doi: 10.1016/j.cclet.2020.04.035
14. [14]
  L. Chen, Z. Liu, R. Jin, et al., J. Mater. Chem. B 6 (2018) 6262-6268 doi: 10.1039/c8tb01182f
15. [15]
  Y. Song, D. Li, J. He, et al., Chin. Chem. Lett. 30 (2019) 2027-2031 doi: 10.1016/j.cclet.2019.04.052
16. [16]
  T. Liu, Z. Liu, J. Chen, et al., J. Biomed. Nanotechnol 14 (2018) 1107-1116 doi: 10.1166/jbn.2018.2573
17. [17]
  J. Hu, Y. Xu, Y. Zhang, Chin. Chem. Lett. 30 (2019) 2039-2042 doi: 10.1016/j.cclet.2019.05.017
18. [18]
  X. Jia, Y. Zhang, Y. Zou, et al., Adv. Mater. 30 (2018) e1704490 doi: 10.1002/adma.201704490
19. [19]
  X. Hu, Z. Chai, L. Lu, et al., Adv. Funct. Mater. 29 (2019) 1807941 doi: 10.1002/adfm.201807941
20. [20]
  X. Chen, A.H. Soeriyadi, X. Lu, et al., Adv. Funct. Mater. 24 (2014) 6999-7006 doi: 10.1002/adfm.201402339
21. [21]
  R. Jin, Q. Wang, G. Dou, et al., Appl. Mater. Today 21 (2020) 100883 doi: 10.1016/j.apmt.2020.100883
22. [22]
  I. Gjuroski, E. Girousi, C. Meyer, et al., J. Control. Release 316 (2019) 150-167 doi: 10.1016/j.jconrel.2019.10.010
23. [23]
  Y. Dong, D.J. Siegwart, D.G. Anderson, Adv. Drug. Deliv. Rev. 144 (2019) 133-147 doi: 10.1016/j.addr.2019.05.004
24. [24]
  F. Tosi, M.C.A. Stuart, S.J. Wezenberg, B.L. Feringa, Angew. Chem. Int. Ed. 58 (2019) 14935-14939 doi: 10.1002/anie.201908010
25. [25]
  W. Fan, N. Lu, P. Huang, et al., Angew. Chem. Int. Ed. 56 (2017) 1229-1233 doi: 10.1002/anie.201610682
26. [26]
  W. Fan, B.C. Yung, X. Chen, Angew. Chem. Int. Ed. 57 (2018) 8383-8394 doi: 10.1002/anie.201800594
27. [27]
  M.F. Chung, H.Y. Liu, K.J. Lin, et al., Angew. Chem. Int. Ed. 54 (2015) 9890-9893 doi: 10.1002/anie.201504444
28. [28]
  R. Guo, Y. Tian, Y. Wang, W. Yang, Adv. Funct. Mater. 27 (2017) 1606398 doi: 10.1002/adfm.201606398
29. [29]
  K. Zhang, H. Xu, X. Jia, et al., ACS Nano 10 (2016) 10816-10828 doi: 10.1021/acsnano.6b04921
30. [30]
  W. Fan, N. Lu, P. Huang, et al., Angew. Chem. Int. Ed. 56 (2017) 1229-1233 doi: 10.1002/anie.201610682
31. [31]
  J. An, Y.G. Hu, C. Li, et al., Biomaterials 230 (2020) 119636 doi: 10.1016/j.biomaterials.2019.119636
32. [32]
  S. Kudo, Y. Nagasaki, J. Control. Release 217 (2015) 256-262 doi: 10.1016/j.jconrel.2015.09.019
33. [33]
  Z. Yuan, C. Lin, Y. He, et al., ACS Nano 14 (2020) 3546-3562 doi: 10.1021/acsnano.9b09871
34. [34]
  W. Fan, W. Bu, Z. Zhang, et al., Angew. Chem. Int. Ed. 54 (2015) 14026-14030 doi: 10.1002/anie.201504536
35. [35]
  M. Huo, L. Wang, Y. Chen, J. Shi, Nat. Commun. 8 (2017) 357 doi: 10.1038/s41467-017-00424-8
36. [36]
  W. Zhao, J. Hu, W. Gao, ACS Appl. Mater. Interfaces 9 (2017) 23528-23535 doi: 10.1021/acsami.7b06814
37. [37]
  P.D.W. Eckford, F.J. Sharom, Chem. Rev. 109 (2009) 2989-3011 doi: 10.1021/cr9000226
38. [38]
  G. Minotti, P. Menna, E. Salvatorelli, et al., Pharmacol. Rev. 56 (2004) 185-229 doi: 10.1124/pr.56.2.6
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沈阳化工大学材料科学与工程学院沈阳 110142