Citation: Xiangling Ren, Xinyuan Huang, Qiong Wu, Longfei Tan, Changhui Fu, Yi Chen, Xianwei Meng. Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2[J]. Chinese Chemical Letters, ;2021, 32(10): 3087-3089. doi: 10.1016/j.cclet.2021.03.081 shu

Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2

Xiangling Ren ^{a, b, c, d} ,
Xinyuan Huang ^a ,
Qiong Wu ^{a, c, d} ,
Longfei Tan ^{a, c} ,
Changhui Fu ^{a, c} ,
Yi Chen ^b ,
Xianwei Meng ^{a, c, *,}

a.
Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
c.
CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
d.
University of Chinese Academy of Sciences, Beijing 100049, China

mengxw@mail.ipc.ac.cn

Received Date: 8 February 2021
Revised Date: 31 March 2021
Accepted Date: 1 April 2021
Available Online: 2 April 2021

Figures(3)

Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy. The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase (especially M2-type isozyme, PKM2), the rate limiting enzyme of glycolysis. This is helpful to the treatment of tumor. Herein, metal organic frameworks (MOFs) were found to inhibit the activity of PKM2. Nanoscale ZIF-8 was synthesized by standing and ultrasonic method, respectively. The ZIF-8 has the performance of inhibiting PKM2. Further research showed that the inhibition ability was attributed to zinc ion in ZIF-8. Interestingly, the IC₅₀ of ZIF-8 on PKM2 was one percent of that of zinc ion. This novel enzyme inhibitor is expected to be used in cancer therapy.
- Metal organic frameworks,
- Pyruvate kinase,
- Glycolysis,
- Lactate dehydrogenase,
- Inhibition
1. [1]
  N. Hay, Nat. Rev. Cancer 16 (2016) 635-649 doi: 10.1038/nrc.2016.77
2. [2]
  Y. Wu, J. Wen, H. Li, S. Sun, Y. Xu, Chin. Chem. Lett. 28 (2017) 1916-1924 doi: 10.1016/j.cclet.2017.09.032
3. [3]
  M. Liu, X. Ren, X. Liu, et al., Chin. Chem. Lett. 31 (2020) 3117-3120 doi: 10.1016/j.cclet.2020.06.024
4. [4]
  J. Chen, Z. Jiang, B. Wang, Y. Wang, X. Hu, Cancer Lett. 316 (2012) 204-210 doi: 10.1016/j.canlet.2011.10.039
5. [5]
  S. Masaki, K. Hashimoto, D. Kihara, et al., Biochem. Biophys. Res. Commun. 526 (2020) 973-977 doi: 10.1016/j.bbrc.2020.03.182
6. [6]
  K. Taniguchi, N. Sugito, M. Kumazaki, et al., Cancer Lett. 363 (2015) 17-27 doi: 10.1016/j.canlet.2015.03.026
7. [7]
  M.G.V. Heiden, L.C. Cantley, C.B. Thompson, Science 324 (2009) 1029-1033 doi: 10.1126/science.1160809
8. [8]
  J. Chen, J. Xie, Z. Jiang, et al., Oncogene 30 (2011) 4297-4306 doi: 10.1038/onc.2011.137
9. [9]
  W.J. Israelsen, M.G.V. Heiden, Semin. Cell Dev. Biol. 43 (2015) 43-51 doi: 10.1016/j.semcdb.2015.08.004
10. [10]
  X. Chen, S. Chen, D. Yu, Cancer Cell Int. 20 (2020) 523 doi: 10.1109/itoec49072.2020.9141700
11. [11]
  S. Amin, P. Yang, Z. Li, Biochim. Biophys. Acta. Rev. Cancer 1871 (2019) 331-341 doi: 10.1016/j.bbcan.2019.02.003
12. [12]
  M. Zhou, Y. Zhao, Y. Ding, et al., Mol. Cancer 9 (2010) 33
13. [13]
  W.H. Koppenol, P.L. Bounds, C.V. Dang, Nat. Rev. Cancer 11 (2011) 325-337 doi: 10.1038/nrc3038
14. [14]
  M. Upadhyay, J. Samal, M. Kandpal, O.V. Singh, P. Vivekanandan, Pharmacol. Ther. 137 (2013) 318-330 doi: 10.1016/j.pharmthera.2012.11.003
15. [15]
  H.R. Christofk, M.G.V. Heiden, M.H. Harris, et al., Nature 452 (2008) 230-233 doi: 10.1038/nature06734
16. [16]
  Y.D. Zebral, Jda. S. Fonseca, M. Roza, et al., Chemosphere 253 (2020) 126631 doi: 10.1016/j.chemosphere.2020.126631
17. [17]
  Jda. S. Fonseca, Y.D. Zebral, A. Bianchini, Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 240 (2021) 108924 doi: 10.1016/j.cbpc.2020.108924
18. [18]
  L. Canesi, M. Betti, C. Ciacci, G. Gallo, Gen. Comp. Endocrinol. 122 (2001) 60-66 doi: 10.1006/gcen.2001.7612
19. [19]
  I.S.A. Anni, Y.D. Zebral, S.B. Afonso, et al., Chemosphere 227 (2019) 580-588 doi: 10.1016/j.chemosphere.2019.04.080
20. [20]
  K. Murakami, M. Yoshino, Biometals 30 (2017) 335-340 doi: 10.1007/s10534-017-0009-y
21. [21]
  S. Li, L. Tan, X. Meng, Adv. Funct. Mater. 30 (2020) 1908924 doi: 10.1002/adfm.201908924
22. [22]
  Y. Wang, W. Wu, J. Liu, et al., ACS Nano 13 (2019) 6879-6890 doi: 10.1021/acsnano.9b01665
23. [23]
  W.H. Chen, M. Vázquez-González, A. Zoabi, R. Abu-Reziq, I. Willner, Nat. Catal. 1 (2018) 689-695 doi: 10.1038/s41929-018-0117-2
24. [24]
  Y. Wang, L. Yan, K. Dastafkan, et al., Adv. Mater. (2021) 2006351 doi: 10.1002/adma.202006351
25. [25]
  Y. Zou, W. Zhang, H. Zhou, et al., Chin. Chem. Lett. 30 (2019) 481-484 doi: 10.1016/j.cclet.2018.06.016
26. [26]
  Y. Ding, H. Xu, C. Xu, et al., Adv. Sci. 7 (2020) 2001060 doi: 10.1002/advs.202001060
27. [27]
  L. Su, Q. Wu, L. Tan, et al., ACS Appl. Mater. Interfaces 11 (2019) 10520-10531 doi: 10.1021/acsami.8b22177
28. [28]
  S. Shan, J. Shi, P. Yang, et al., J. Agric. Food Chem. 65 (2017) 8136-8144 doi: 10.1021/acs.jafc.7b02757
29. [29]
  W. Guo, Z. Chen, L. Tan, et al., Chem. Comm. 56 (2020) 3919-3922 doi: 10.1039/c9cc09712k
30. [30]
  H. Li, X. Lu, Q. Lu, et al., Chem. Comm. 56 (2020) 4724-4727 doi: 10.1039/d0cc00748j
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