Citation: Zhuoting Deng, Chao Jiang, Muhammad Rizwan Younis, Shan Lei, Yaling He, Haoxing Zheng, Peng Huang, Jing Lin. Mild hyperthermia-enhanced chemo-photothermal synergistic therapy using doxorubicin-loaded gold nanovesicles[J]. Chinese Chemical Letters, ;2021, 32(8): 2411-2414. doi: 10.1016/j.cclet.2021.03.080 shu

Mild hyperthermia-enhanced chemo-photothermal synergistic therapy using doxorubicin-loaded gold nanovesicles

Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China

jingl@szu.edu.cn

Received Date: 14 December 2020
Revised Date: 29 March 2021
Accepted Date: 30 March 2021
Available Online: 31 March 2021

Figures(5)

Gold nanovesicles (GVs) with unique plasmonic property and large cavity hold great potential as a stimuli-responsive nanocarrier to deliver drugs for efficient tumor chemotherapy and other therapies synergistically. Herein, we developed doxorubicin-loaded gold nanovesicles (DGVs), offering infrared thermal (IRT) and photoacoustic (PA) dual-modal imaging guided mild hyperthermia-enhanced chemo-photothermal cancer synergistic therapy. The DGVs are self-assembled by gold nanoparticles modified with amphiphilic copolymer in a predetermined concentration of doxorubicin through film rehydration method. Under the influence of laser excitation, the as-prepared DGVs exhibited good photothermal effect, which triggered the structural disruption of GVs and thus, allowed the efficient release of encapsulated DOX to enhance cell uptake for fluorescence imaging and tumor chemotherapy, respectively. In addition, DGVs also showed a strong PA and IRT signals in vivo. Our study demonstrated the potential of DGVs as stimuli-responsive drug delivery systems and cancer theranostics.
- Mild hyperthermia,
- Chemo-photothermal synergistic therapy,
- Gold nanovesicles,
- Doxorubicin,
- Photoacoustic imaging
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