Citation: Deming He, Minmin Yan, Pengjuan Sun, Yuanqiang Sun, Lingbo Qu, Zhaohui Li. Recent progress in carbon-dots-based nanozymes for chemosensing and biomedical applications[J]. Chinese Chemical Letters, ;2021, 32(10): 2994-3006. doi: 10.1016/j.cclet.2021.03.078 shu

Recent progress in carbon-dots-based nanozymes for chemosensing and biomedical applications

College of Chemistry, Green Catalysis Center, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, Zhengzhou Key Laboratory of Functional Nanomaterial and Medical Theranostic, Zhengzhou University, Zhengzhou 450001, China

sunyq@zzu.edu.cn

zhaohui.li@zzu.edu.cn

Received Date: 24 February 2021
Revised Date: 29 March 2021
Accepted Date: 30 March 2021
Available Online: 31 March 2021

Figures(29)

Nanozymes are nanomaterials with enzyme-like activities that efficiently overcome the drawbacks of natural enzymes in biosensing, detection, and biomedical fields, and they are the most widely used artificial enzymes. Owing to their excellent catalytic characteristics, biocompatibility, and environmental favorability, carbon-dots-based (CDs) nanozymes have inspired a research upsurge. However, no review focusing on CDs nanozymes has been published, even though substantial advances have been achieved. Herein, the advances, catalytic activities, and applications of CDs nanozymes are highlighted and summarized. In addition, the critical issues and challenges of researching nanozymes are discussed. We hope that this review will broaden the horizons of nanozymes and CDs nanozymes, as well as promote their development.
- Carbon dots,
- Nanozyme,
- Chemosensing,
- Catalytic activity,
- Bioimaging
1. [1]
  M. Liang, X. Yan, Acc. Chem. Res. 52(2019) 2190-2200. doi: 10.1021/acs.accounts.9b00140
2. [2]
  X. Zhang, S. Lin, S. Liu, et al., Coord. Chem. Rev. 429(2021) 213652. doi: 10.1016/j.ccr.2020.213652
3. [3]
  P. Li, C. Wu, Y. Xu, et al., TrAC Trends Anal. Chem. 131(2020) 116007. doi: 10.1016/j.trac.2020.116007
4. [4]
  D. Jiang, D. Ni, Z.T. Rosenkrans, et al., Chem. Soc. Rev. 48(2019) 3683-3704. doi: 10.1039/C8CS00718G
5. [5]
  L. Gao, J. Zhuang, L. Nie, et al., Nat. Nanotechnol. 2(2007) 577-583. doi: 10.1038/nnano.2007.260
6. [6]
  F. Manea, F.B. Houillon, L. Pasquato, P. Scrimin, Angew. Chem. Int. Ed. 43(2004) 6165-6169. doi: 10.1002/anie.200460649
7. [7]
  J. Wu, X. Wang, Q. Wang, et al., Chem. Soc. Rev. 48(2019) 1004-1076. doi: 10.1039/C8CS00457A
8. [8]
  H. Qin, Y. Sun, X. Geng, et al., Anal. Chim. Acta. 1106(2020) 207-215. doi: 10.1016/j.aca.2020.02.002
9. [9]
  X. Geng, Y. Sun, Y. Guo, et al., Anal. Chem. 92(2020) 7940-7946. doi: 10.1021/acs.analchem.0c01335
10. [10]
  X. Shi, H. Meng, Y. Sun, et al., Small 15(2019) 1901507. doi: 10.1002/smll.201901507
11. [11]
  C. Long, Z. Jiang, J. Shangguan, et al., Chem. Eng. J. 406(2021) 126848. doi: 10.1016/j.cej.2020.126848
12. [12]
  S. Lu, L. Sui, J. Liu, et al., Adv. Mater. 29(2017) 1603443. doi: 10.1002/adma.201603443
13. [13]
  H. Song, X. Liu, B. Wang, Z. Tang, S. Lu, Sci. Bull. 64(2019) 1788-1794. doi: 10.1016/j.scib.2019.10.006
14. [14]
  H. Liu, Y. Sun, Z. Li, et al., Chin. Chem. Lett. 30(2019) 1647-1651. doi: 10.1016/j.cclet.2019.06.012
15. [15]
  Y. Sun, H. Qin, X. Geng, et al., ACS Appl. Mater. Interfaces. 12(2020) 31738-31744. doi: 10.1021/acsami.0c05005
16. [16]
  C. Xia, S. Zhu, T. Feng, M. Yang, B. Yang, Adv. Sci. 6(2019) 1901316. doi: 10.1002/advs.201901316
17. [17]
  M.L. Liu, B.B. Chen, C.M. Li, C.Z. Huang, Green. Chem. 21(2019) 449-471. doi: 10.1039/C8GC02736F
18. [18]
  X. Geng, Y. Sun, Z. Li, et al., Small 15(2019) 1901517. doi: 10.1002/smll.201901517
19. [19]
  H. Liu, Y. Sun, Z. Li, et al., Nanoscale 11(2019) 8458-8463. doi: 10.1039/C9NR01678C
20. [20]
  W. Li, Y. Liu, B. Wang, et al., Chin. Chem. Lett. 30(2019) 2323-2327. doi: 10.1016/j.cclet.2019.06.040
21. [21]
  B. Wang, J. Li, Z. Tang, B. Yang, S. Lu, Sci. Bull. 64(2019) 1285-1292. doi: 10.1016/j.scib.2019.07.021
22. [22]
  J. Fan, P.K. Chu, Small 6(2010) 2080-2098. doi: 10.1002/smll.201000543
23. [23]
  J. Wu, S. Li, H. Wei, Chem. Commun. 54(2018) 6520-6530. doi: 10.1039/C8CC01202D
24. [24]
  Y. Zhou, B. Liu, R. Yang, J. Liu, Bioconjugate Chem. 28(2017) 2903-2909. doi: 10.1021/acs.bioconjchem.7b00673
25. [25]
  J. Wu, S. Li, H. Wei, Nanoscale Horiz. 3(2018) 367-382. doi: 10.1039/C8NH00070K
26. [26]
  Y. Li, W. Zhu, J. Li, H. Chu, Colloid. Surf. B. 198(2021) 111465. doi: 10.1016/j.colsurfb.2020.111465
27. [27]
  A. Kumar, S. Das, P. Munusamy, et al., Environ. Sci. Nano 1(2014) 516-532. doi: 10.1039/C4EN00052H
28. [28]
  B. Unnikrishnan, C.W. Lien, H.W. Chu, C.C. Huang, J. Hazard. Mater. 401(2021) 123397. doi: 10.1016/j.jhazmat.2020.123397
29. [29]
  A. Hasan, N.M.Q. Nanakali, A. Salihi, et al., Talanta 215(2020) 120939. doi: 10.1016/j.talanta.2020.120939
30. [30]
  W. Wang, S. Gunasekaran, TrAC Trends Anal. Chem. 126(2020) 115841. doi: 10.1016/j.trac.2020.115841
31. [31]
  M. Shamsipur, A. Safavi, Z. Mohammadpour, Sens. Actuators B: Chem. 199(2014) 463-469. doi: 10.1016/j.snb.2014.04.006
32. [32]
  S. Yousefinejad, H. Rasti, M. Hajebi, et al., Sens. Actuators B: Chem. 247(2017) 691-696. doi: 10.1016/j.snb.2017.02.145
33. [33]
  J. Guo, Y. Wang, M. Zhao, Sens. Actuators B: Chem. 297(2019) 126739. doi: 10.1016/j.snb.2019.126739
34. [34]
  J. Shi, T. Yin, W. Shen, Colloid. Surfaces. B 178(2019) 163-169. doi: 10.1016/j.colsurfb.2019.03.012
35. [35]
  L. Zhao, Z. Wu, G. Liu, et al., J. Mater. Chem. B 7(2019) 7042-7051.
36. [36]
  C.Y. Chen, Y.Z. Tan, P.H. Hsieh, et al., ACS Sensors 5(2020) 1314-1324. doi: 10.1021/acssensors.9b02486
37. [37]
  Y. Liu, Q. Zhou, Y. Yuan, Y. Wu, Carbon 115(2017) 550-560. doi: 10.1016/j.carbon.2017.01.035
38. [38]
  F. Wang, C. Zhang, Q. Xue, H. Li, Y. Xian, Biosens. Bioelectron. 95(2017) 21-26. doi: 10.1016/j.bios.2017.04.010
39. [39]
  N. Shao, H. Wang, X. Gao, R. Yang, W. Chan, Anal. Chem. 82(2010) 4628-4636. doi: 10.1021/ac1008089
40. [40]
  Q. Li, D. Yang, Y. Yang, Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 244(2021) 118882. doi: 10.1016/j.saa.2020.118882
41. [41]
  H.W. Yang, P. Xu, B. Ding, et al., Eur. J. Inorg. Chem. 48(2019) 5077-5084.
42. [42]
  R. Amini, E. Rahimpour, A. Jouyban, Anal. Chim. Acta 1117(2020) 9-17. doi: 10.1016/j.aca.2020.04.001
43. [43]
  Y. Guo, L. Zhang, S. Zhang, et al., Biosens. Bioelectron. 63(2015) 61-71. doi: 10.1016/j.bios.2014.07.018
44. [44]
  X. Wang, Y. Lu, K. Hua, D. Yang, Y. Yang, Anal. Bioanal. Chem. 413(2021) 1373-1382. doi: 10.1007/s00216-020-03100-x
45. [45]
  A. Ibarbia, L. Sánchez-Abella, L. Lezama, H.J. Grande, V. Ruiz, Appl. Surf. Sci. 527(2020) 146937. doi: 10.1016/j.apsusc.2020.146937
46. [46]
  F. Li, Q. Chang, N. Li, et al., Chem. Eng. J. 394(2020) 125045. doi: 10.1016/j.cej.2020.125045
47. [47]
  Y. Li, W. Ma, J. Sun, et al., Carbon. 159(2020) 149-160. doi: 10.1016/j.carbon.2019.11.093
48. [48]
  M. Liang, Y. Wang, K. Ma, et al., Small. 16(2020) 2002348. doi: 10.1002/smll.202002348
49. [49]
  L. Su, Y. Cai, L. Wang, et al., Microchim. Acta. 187(2020) 132. doi: 10.1007/s00604-019-4103-4
50. [50]
  D. Yang, Q. Li, S.K. Tammina, Z. Gao, Y. Yang, Sens. Actuators B: Chem. 319(2020) 128273. doi: 10.1016/j.snb.2020.128273
51. [51]
  C. Li, Q. Liu, X. Wang, Y. Luo, Z. Jiang, Microchem. J. 159(2020) 105508. doi: 10.1016/j.microc.2020.105508
52. [52]
  F. Li, N. Li, C. Xue, et al., Chem. Eng. J. 382(2020) 122484. doi: 10.1016/j.cej.2019.122484
53. [53]
  F. Vetr, Z. Moradi-Shoeili, S. Özkar, Appl. Organomet. Chem. 32(2018) e4465. doi: 10.1002/aoc.4465
54. [54]
  P. Ling, Q. Zhang, T. Cao, F. Gao, Angew. Chem. Int. Ed. 57(2018) 6819-6824. doi: 10.1002/anie.201801369
55. [55]
  J. Zhang, X. Lu, D. Tang, et al., ACS Appl. Mater. Interfaces 10(2018) 40808-40814. doi: 10.1021/acsami.8b15318
56. [56]
  X. Ren, J. Liu, J. Ren, F. Tang, X. Meng, Nanoscale 7(2015) 19641-19646. doi: 10.1039/C5NR04685H
57. [57]
  J. Zhang, S. Wu, X. Lu, P. Wu, J. Liu, Nano Lett. 19(2019) 3214-3220. doi: 10.1021/acs.nanolett.9b00725
58. [58]
  F. Honarasa, F. Peyravi, H. Amirian, J. Iran. Chem. Soc. 17(2020) 507-512. doi: 10.1007/s13738-019-01787-z
59. [59]
  S. Li, E. Pang, C. Gao, et al., Chem. Eng. J. 397(2020) 125471. doi: 10.1016/j.cej.2020.125471
60. [60]
  A. Sun, L. Mu, X. Hu, ACS Appl. Mater. Interfaces. 9(2017) 12241-12252. doi: 10.1021/acsami.7b00306
61. [61]
  L. Zhao, X. Ren, J. Zhang, et al., New J. Chem. 44(2020) 1988-1992. doi: 10.1039/C9NJ05655F
62. [62]
  M. Passi, V. Kumar, G. Packirisamy, Mater. Sci. Eng. C 107(2020) 110255. doi: 10.1016/j.msec.2019.110255
63. [63]
  K. Dehvari, S.H. Chiu, J.S. Lin, et al., Acta Biomater. 114(2020) 343-357. doi: 10.1016/j.actbio.2020.07.022
64. [64]
  H. Wang, Q. Lu, Y. Liu, et al., Sens. Actuators B: Chem. 250(2017) 429-435. doi: 10.1016/j.snb.2017.04.117
65. [65]
  R.E. Cuenca, W.J. Pories, J. Bray, Biol. Trace Elem. Res. 16(1988) 151-154. doi: 10.1007/BF02797099
66. [66]
  Y. Fuse, N. Saito, T. Tsuchiya, Y. Shishiba, M. Irie, Thyroid 17(2007) 145-155. doi: 10.1089/thy.2006.0209
67. [67]
  C. Ren, X. Hu, Q. Zhou, Adv. Sci. 5(2018) 1700595. doi: 10.1002/advs.201700595
68. [68]
  B. Jiang, D. Duan, L. Gao, et al., Nat. Protoc. 13(2018) 1506-1520. doi: 10.1038/s41596-018-0001-1
69. [69]
  H. Wang, K. Wan, X. Shi, Adv. Mater. 31(2019) 1805368. doi: 10.1002/adma.201805368
70. [70]
  M.K. Nazeeruddin, F.D. Angelis, S. Fantacci, et al., J. Am. Chem. Soc. 127(2005) 16835-16847. doi: 10.1021/ja052467l
71. [71]
  Z. Zhang, Y. Liu, X. Zhang, J. Liu, Nano Lett. 17(2017) 7926-7931. doi: 10.1021/acs.nanolett.7b04298
72. [72]
  E. Golub, H.B. Albada, W.C. Liao, Y. Biniuri, I. Willner, J. Am. Chem. Soc. 138(2016) 164-172. doi: 10.1021/jacs.5b09457
73. [73]
  L. He, Y. Li, Q. Wu, et al., ACS Appl. Mater. Interfaces 11(2019) 29158-29166. doi: 10.1021/acsami.9b09283
74. [74]
  Y. Shen, L. Liang, S. Zhang, et al., Nanoscale 10(2018) 1622-1630. doi: 10.1039/C7NR08636A
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