Citation: Yishen Liu, Yuzhen Yuzhen, Tian Tian, Wumei Wang, Jinxia Nong, Xue Qiao, Fuchun Xu, Jianfeng Gao, Xuechuan Hong. Novel CD-MOF NIR-II fluorophores for gastric ulcer imaging[J]. Chinese Chemical Letters, ;2021, 32(10): 3061-3065. doi: 10.1016/j.cclet.2021.03.075 shu

Novel CD-MOF NIR-II fluorophores for gastric ulcer imaging

Yishen Liu ^{a, b, d, 1} ,
Yuzhen Yuzhen ^{a, 1} ,
Tian Tian ^{a, b, 1} ,
Wumei Wang ^{a, 1} ,
Jinxia Nong ^{b, d} ,
Xue Qiao ^{a, b} ,
Fuchun Xu ^a ,
Jianfeng Gao ^{c, **,} ,
Xuechuan Hong ^{a, b, d, *,}

a.
State Key Laboratory of Virology, College of Science, Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control, Medical College, Tibet University, Lhasa 850000, China
b.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China
c.
Center for Animal Experiment, Wuhan University, Wuhan 430071, China
d.
Shenzhen Institute of Wuhan University, Shenzhen 518057, China

^**

jfgao@whu.edu.cn

xhy78@whu.edu.cn

Received Date: 11 February 2021
Revised Date: 29 March 2021
Accepted Date: 30 March 2021
Available Online: 31 March 2021

Figures(5)

Gastric ulcers are one of the most common stomach diseases that often accompanied by inflammation, congestion, edema, scar tissue formation, and pyloric obstruction. Fiberoptic endoscopy and X-ray analysis of the upper GI tract have become the diagnostic procedure of choice for patients. However, conventional diagnosis technology is either invasive or radioactive. Herein, a novel CD-MOF NIR-II fluorophore (GPs-CH1055) was developed. The relative fluorophore intensity was largely consistent at various media and pH buffers, and it can swell into gel particles in solvents and be completely expelled from the gastrointestinal tract without being assimilated. GPs-CH1055 has been further evaluated in vivo, and exhibited strong retention effect on the gastric ulcer sites, bright NIR-II signals with high spatial and temporal resolution. Therefore, GPs-CH1055 shows great promise for realizing real-time gastric ulcer imaging and diagnosis.
- Gastric ulcer,
- NIR-II bioimaging,
- Cyclodextrin metal-organic frameworks,
- Real time,
- Diagnose
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