Citation: Jintao Shen, Jia Liu, Shuo Yu, Yunzhou Yu, Chao Huang, Xianghua Xiong, Junjie Yue, Qiuyun Dai. Diaminodiacid bridge improves enzymatic and in vivo inhibitory activity of peptide CPI-1 against botulinum toxin serotype A[J]. Chinese Chemical Letters, ;2021, 32(12): 4049-4052. doi: 10.1016/j.cclet.2021.03.055 shu

Diaminodiacid bridge improves enzymatic and in vivo inhibitory activity of peptide CPI-1 against botulinum toxin serotype A

Beijing Institute of Biotechnology, Beijing 100071, China

yue_junjie@126.com

daiqy@bmi.ac.cn

Received Date: 29 January 2021
Revised Date: 4 March 2021
Accepted Date: 22 March 2021
Available Online: 23 March 2021

Figures(5)

The replacement of the disulfide bridge of CPI-1, a peptide inhibitor of light chain of Botulinum toxin serotype A, with the thioether-containing and biscarba-containing diaminodiacid bridge leads to a significant decrease in the degradation by trypsin and increase in the detoxification activity in vivo, the addition of hydrophobic or positive amino acid at C-terminus of modified peptides further improves the inhibitory activity.
- Botulinum neurotoxin serotype A,
- Light chain inhibitor,
- Peptide CPI-1,
- Diaminodiacid bridges,
- Inhibitory activity
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