Citation: Chonggui Qiu, Ziyi Cheng, Chuanzhu Lv, Rui Wang, Fabiao Yu. Development of bioorthogonal SERS imaging probe in biological and biomedical applications[J]. Chinese Chemical Letters, ;2021, 32(8): 2369-2379. doi: 10.1016/j.cclet.2021.03.016 shu

Development of bioorthogonal SERS imaging probe in biological and biomedical applications

Chonggui Qiu ¹ ,
Ziyi Cheng ¹ ,
Chuanzhu Lv ^*, ,
Rui Wang ^*, ,
Fabiao Yu ^*,

The First Affiliated Hospital of Hainan Medical University, Key Laboratory of Emergency and Trauma, Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, Institute of Functional Materials and Molecular Imaging, College of Pharmacy, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China

lyuchuanzhu@hainmc.edu.cn

wangrui@hainmc.edu.cn

yufabiao@hainmc.edu.cn

Received Date: 14 January 2021
Revised Date: 5 March 2021
Accepted Date: 7 March 2021
Available Online: 9 March 2021

Figures(5)

Living-cell imaging demands high specificity, sensitivity, and minimal background interference to the targets of interest. However, developing a desirable imaging probe that can possess all the above features is still challenging. The bioorthogonal surface-enhanced Raman scattering (SERS) imaging has been recently emerged through utilizing Raman reporters with characteristic peaks in Raman-silent region of cells (1800-2800 cm^-1), which opens a revolutionary avenue for living-cell imaging with multiplexing capability. In this review, we focus on the recent advances in the technology development and the biological and biomedical applications of the living-cell bioorthogonal SERS imaging technique. After introduction of fundamental principles for bioorthogonal tag or label, we present applications for visualization of various intracellular components and environment including proteins, nucleic acids, lipids, pH and hypoxia, even for cancer diagnosis in tissue samples. Then, various bioorthogonal SERS imaging-guided therapy strategies have been discussed such as phototherapy and surgery. In conclusion, this strategy has great potential to be a flexible and robust tool for visualization detection and diseases diagnosis.
- Surface-enhanced Raman scattering (SERS),
- Bioorthogonal molecule,
- Visualization,
- Disease diagnosis,
- Therapy
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