Citation: Xianghua Wu, Yuxun Lu, Bo Liu, Yu Chen, Junfeng Zhang, Ying Zhou. A H₂S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging[J]. Chinese Chemical Letters, ;2021, 32(8): 2380-2384. doi: 10.1016/j.cclet.2021.02.065 shu

A H₂S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging

Xianghua Wu ^{a, 1} ,
Yuxun Lu ^{b, 1} ,
Bo Liu ^a ,
Yu Chen ^a ,
Junfeng Zhang ^{a, *,} ,
Ying Zhou ^{b, *,}

a.
College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China
b.
College of Chemical Science and Technology, Yunnan University, Kunming 650091, China

junfengzhang78@126.com

yingzhou@ynu.edu.cn

Received Date: 2 January 2021
Revised Date: 24 February 2021
Accepted Date: 26 February 2021
Available Online: 1 March 2021

Figures(7)

Hydrogen sulfide (H₂S) is a signaling molecule that plays important roles in biological systems. The exploration of H₂S as a new drug release trigger and its related fluorescent theranostic system is crucial for cancer bio-imaging and therapy. Herein, we designed a new two-photon ratiometric fluorescent theranostic prodrug (compound 1) and studied its spectroscopic properties and application in in vivo imaging. Compound 1 specifically reacted with H₂S and released the free active therapeutic component of 7-ethyl-10-hydroxycamptothecin, which was accompanied with a red-shift fluorescence emission signal from 460 nm to 545 nm. The exogenous and endogenous H₂S in living cells were imaged by compound 1 under one-photon and two-photon excitation. Furthermore, compound 1 monitored the H₂S concentration changes in Caenorhabditis elegans by fluorescence imaging. Additionally, it showed effective drug release activation in situ tumor with exogenous and endogenous H₂S as the trigger. The H₂S-sensitive activation and drug-release properties highlight the potential of theranostic compound 1 in future cancer treatment and therapy.
- Hydrogen sulfide,
- Two-photon,
- Ratiometric fluorescent,
- Theranostic prodrug,
- Bio-imaging
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沈阳化工大学材料科学与工程学院沈阳 110142

A H2S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging

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通讯作者: 陈斌, bchen63@163.com

A H₂S-triggered two-photon ratiometric fluorescent theranostic prodrug for bio-imaging