Citation: Yuncan Chen, Shan Lv, Ruizhi Lai, Yingying Xu, Xin Huang, Jianglian Li, Guanghui Lv, Yong Wu. Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas[J]. Chinese Chemical Letters, ;2021, 32(8): 2555-2558. doi: 10.1016/j.cclet.2021.02.052 shu

Synthesis of 2-aminothiazoles via rhodium-catalyzed carbenoid insertion/annulation of sulfoxonium ylides with thioureas

Yuncan Chen ^a ,
Shan Lv ^a ,
Ruizhi Lai ^a ,
Yingying Xu ^a ,
Xin Huang ^a ,
Jianglian Li ^a ,
Guanghui Lv ^{b, *,} ,
Yong Wu ^{a, *,}

a.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
b.
Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

1083947919@qq.com

wyong@scu.edu.cn

Received Date: 21 December 2020
Revised Date: 20 February 2021
Accepted Date: 22 February 2021
Available Online: 26 February 2021

Figures(5)

Sulfoxonium ylides as carbene precursors couple smoothly with thioureas in the presence of 5 mol% of rhodium(Ⅱ) acetate dimmer via carbenoid insertion to afford the corresponding 2-aminothiazoles with high chemoselectivity, providing a facile and efficient approach to access a variety of 2-aminothiazole derivatives with good functional groups tolerance.
- 2-Aminothiazoles,
- Carbene,
- Rhodium,
- Sulfoxonium ylides,
- Annulation
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