Citation: Ning Chen, Wenhui Fu, Jie Zhou, Linqiang Mei, Jimin Yang, Yang Tian, Qiang Wang, Wenyan Yin. Mn²⁺-doped ZrO₂@PDA nanocomposite for multimodal imaging-guided chemo-photothermal combination therapy[J]. Chinese Chemical Letters, ;2021, 32(8): 2405-2410. doi: 10.1016/j.cclet.2021.02.030 shu

Mn²⁺-doped ZrO₂@PDA nanocomposite for multimodal imaging-guided chemo-photothermal combination therapy

Ning Chen ^{a, 1} ,
Wenhui Fu ^{a, 1} ,
Jie Zhou ^{b, 1} ,
Linqiang Mei ^{b, 1} ,
Jimin Yang ^c ,
Yang Tian ^a ,
Qiang Wang ^{a, *,} ,
Wenyan Yin ^{b, d, *,}

a.
Laboratory for Micro-sized Functional Materials, Department of Chemistry and College of Elementary Education, Capital Normal University, Beijing 100048, China
b.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Beijing Metallomics Facility, National Consortium for Excellence in Metallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
c.
School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China
d.
Laboratory of Nano-Bio Interface, Suzhou Institute of NanoTech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China

qwchem@gmail.com

yinwy@ihep.ac.cn

Received Date: 27 December 2020
Revised Date: 17 February 2021
Accepted Date: 17 February 2021
Available Online: 19 February 2021

Figures(5)

Developing low toxicity and multifunctional theranostic nanoplatform is the key for precise cancer diagnosis and treatment. Herein, an inorganic-organic hybrid nanocomposite is designed by modifying zirconium dioxide (ZrO₂) with polydopamine (PDA) followed by doping Mn²⁺ ions and functionalizing with Tween 20 (Tween-ZrO₂@PDA-Mn²⁺) for multimodal imaging and chemo-photothermal combination therapy. The as-prepared nanocomposite exhibits good biocompatibility in vitro and in vivo. Specifically, it can be employed as a multifunctional platform not only for computed tomography (CT) imaging and T₁-weighted magnetic resonance (MR) imaging, but also for efficient chemotherapeutic drug doxorubicin hydrochloride (DOX) loading. Importantly, because of the pronounced photothermal conversion performance and controllable DOX release ability triggered by the near-infrared (NIR) irradiation and acidic pH, the synergistic effect between photothermal therapy and chemotherapy results in an enhanced cancer treatment efficacy in vivo. Our work provides a high-performance inorganic-organic hybrid nanotheranostic platform for chemo-photothermal cancer therapy guided by CT and MR imaging.
- ZrO₂ nanoparticles,
- Polydopamine,
- Multimodal imaging,
- Chemo-photothermal therapy
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沈阳化工大学材料科学与工程学院沈阳 110142

Mn2+-doped ZrO2@PDA nanocomposite for multimodal imaging-guided chemo-photothermal combination therapy

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通讯作者: 陈斌, bchen63@163.com

Mn²⁺-doped ZrO₂@PDA nanocomposite for multimodal imaging-guided chemo-photothermal combination therapy