Citation: Zijin Cheng, Tian Zhang, Weili Wang, Qing Shen, Ying Hong, Jinjun Shao, Xiaoji Xie, Zhenghao Fei, Xiaochen Dong. D-A-D structured selenadiazolesbenzothiadiazole-based near-infrared dye for enhanced photoacoustic imaging and photothermal cancer therapy[J]. Chinese Chemical Letters, ;2021, 32(4): 1580-1585. doi: 10.1016/j.cclet.2021.02.017 shu

D-A-D structured selenadiazolesbenzothiadiazole-based near-infrared dye for enhanced photoacoustic imaging and photothermal cancer therapy

Zijin Cheng ^a ,
Tian Zhang ^a ,
Weili Wang ^a ,
Qing Shen ^a ,
Ying Hong ^a ,
Jinjun Shao ^{a, *,} ,
Xiaoji Xie ^a ,
Zhenghao Fei ^{b, *,} ,
Xiaochen Dong ^{a, c}

a.
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 210009, China
b.
Applied Chemistry & Environmental Engineering, Yancheng Teachers University, Yancheng 224051, China
c.
School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing 210044, China

iamjjshao@njtech.edu.cn

feizhenghao@163.com

Received Date: 15 January 2021
Revised Date: 7 February 2021
Accepted Date: 9 February 2021
Available Online: 11 February 2021

Figures(5)

Near-infrared (NIR) small molecular organic dyes as photothermal agents for cancer photothermal therapy (PTT) have attracted considerable research attention. Herein, two donor-acceptor-donor (D-A-D) structured NIR dyes, BBTT and SeBTT, are rationally designed, where the only difference is one heteroatom within the acceptor unit varying from sulfur to selenium (Se). More importantly, SeBTT NPs exhibit stronger NIR absorbance and higher photothermal conversion efficiency (PTCE ≈ 65.3%). In vivo experiments illustrate that SeBTT NPs can be utilized as a high contrast photoacoustic imaging (PAI) agent, and succeed in tumor suppression without noticeable damage to main organs under NIR photoirradiation. This study presents an effective molecular heteroatom surgery strategy to regulate the photothermal properties of NIR small molecules for enhanced PAI and PTT.
- Photothermal,
- Near-infrared dye,
- Cancer therapy,
- Donor-acceptor,
- Selenadiazolesbenzothiadiazole
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