Citation: Xiaolong Hu, Shuna Wang, Qinghua Luo, Binghui Ge, Qin Cheng, Chen Dong, Jiahui Xu, Haizhen Ding, Mingsheng Xu, Antonio Claudio Tedesco, Xin Huang, Renquan Zhang, Hong Bi. Synthesis of Sn nanocluster@carbon dots for photodynamic therapy application[J]. Chinese Chemical Letters, ;2021, 32(7): 2287-2291. doi: 10.1016/j.cclet.2021.01.039 shu

Synthesis of Sn nanocluster@carbon dots for photodynamic therapy application

Xiaolong Hu ^{a, 1} ,
Shuna Wang ^{a, 1} ,
Qinghua Luo ^a ,
Binghui Ge ^b ,
Qin Cheng ^a ,
Chen Dong ^a ,
Jiahui Xu ^a ,
Haizhen Ding ^a ,
Mingsheng Xu ^a ,
Antonio Claudio Tedesco ^{a, c} ,
Xin Huang ^d ,
Renquan Zhang ^d ,
Hong Bi ^{a, *,}

a.
School of Chemistry and Chemical Engineering, Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, Hefei 230601, China
b.
Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China
c.
Department of Chemistry, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-901, Brazil
d.
Department of Thoracic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China

bihong@ahu.edu.cn

Received Date: 20 December 2020
Revised Date: 17 January 2021
Accepted Date: 18 January 2021
Available Online: 26 January 2021

Figures(5)

Recently, photodynamic therapy (PDT) has been extensively applied in clinical and coadjuvant treatment of various kinds of tumors. However, the photosensitizer (PS) of PDT still lack of high production of singlet oxygen (¹O₂), low cytotoxicity and high biocompatibility. Herein, we propose a facile method for establishing a new core-shell structured Sn nanocluster@carbon dots (CDs) PS. Firstly, Sn⁴⁺@S-CDs complex is synthesized using the sulfur-doped CDs (S-CDs) and SnCl₄ as raw materials, and subsequently the new PS (Sn nanocluster@CDs) is obtained after vaporization of Sn⁴⁺@S-CDs solution. Remarkably, the obtained Sn nanocluster@CDs show an enhanced fluorescence as well as a higher ¹O₂ quantum yield (QY) than S-CDs. The high ¹O₂ QY (58.3%) irradiated by the LED light (400–700 nm, 40 mW/cm²), induce the reduction of 4T1 cancer cells viability by 25%. More intriguingly, no visible damage happens to healthy cells, with little impact on liver tissue due to renal excretion, both in vitro and in vivo experiments demonstrate that Sn nanocluster@CDs may become a promising PS, owning a high potential for application in PDT.
- Sn nanocluster@CDs,
- Photodynamic therapy,
- Photosensitizer,
- Biocompatibility,
- Singlet oxygen
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