Citation: Yonghui Liu, Mingjing Li, Haomiao Zhu, Zhe Jing, Xiaona Yin, Kun Wang, Zhangyong Hong, Wei Zhao. Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine[J]. Chinese Chemical Letters, ;2021, 32(6): 1963-1966. doi: 10.1016/j.cclet.2021.01.035 shu

Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine

Yonghui Liu ^a ,
Mingjing Li ^a ,
Haomiao Zhu ^a ,
Zhe Jing ^b ,
Xiaona Yin ^a ,
Kun Wang ^a ,
Zhangyong Hong ^{b, *,} ,
Wei Zhao ^{a, *,}

a.
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and KLMDASR of Tianjin, Nankai University, Tianjin 300353, China
b.
State Key Laboratory of Medicinal Chemical Biology & Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin 300071, China

hongzy@nankai.edu.cn@126.com

wzhao@nankai.edu.cn

Received Date: 3 December 2020
Revised Date: 18 January 2021
Accepted Date: 19 January 2021
Available Online: 27 January 2021

Figures(6)

We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated inside β-glucan particles (GP-Al). The constructed vaccine induced strong MUC1 antigen specific IgG antibody titers and enhanced CD8⁺ T cells cytotoxic effect to kill tumor cells. These results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines.
- MUC 1 antigen,
- Glycopeptide,
- GP-Al,
- Adjuvant,
- Antitumor vaccine
1. [1]
  S.A. Rosenberg, J.C. Yang, N.P. Restifo, Nat. Med. 10 (2004) 909-915. doi: 10.1038/nm1100
2. [2]
  I. Melero, G. Gaudernack, W. Gerritsen, et al., Nat. Rev. Clin. Oncol. 11 (2014) 509-524. doi: 10.1038/nrclinonc.2014.111
3. [3]
  R.M. Wilson, S.J. Danishefsky, J. Am. Chem. Soc. 135 (2013) 14462-14472. doi: 10.1021/ja405932r
4. [4]
  W.H. Li, Y.M. Li, Chem. Rev. 120 (2020) 11420-11478. doi: 10.1021/acs.chemrev.9b00833
5. [5]
  J.A. Schroeder, A.A. Masri, M.C. Adriance, et al., Oncogene 23 (2004) 5739-5747. doi: 10.1038/sj.onc.1207713
6. [6]
  J. Zhao, G. Hu, Y. Huang, et al., Chin. Chem. Lett. 32 (2021) 1331-1340. doi: 10.1016/j.cclet.2020.10.013
7. [7]
  N. Gaidzik, U. Westerlind, H. Kunz, Chem. Soc. Rev. 42 (2013) 4421-4442. doi: 10.1039/c3cs35470a
8. [8]
  S.J. Danishefsky, J.R. Allen, Angew. Chem. Int. Ed. 39 (2000) 836-863. doi: 10.1002/(SICI)1521-3773(20000303)39:5<836::AID-ANIE836>3.0.CO;2-I
9. [9]
  D. Feng, A.S. Shaikh, F. Wang, ACS Chem. Biol. 11 (2016) 850-863. doi: 10.1021/acschembio.6b00084
10. [10]
  S.J. Danishefsky, J.R. Allen, Angew. Chem. Int. Ed. 39 (2000) 836-863. doi: 10.1002/(SICI)1521-3773(20000303)39:5<836::AID-ANIE836>3.0.CO;2-I
11. [11]
  Y. Gao, Z.Y. Sun, Z.H. Huang, et al., Chem. Eur. J. 20 (2014) 13541-13546. doi: 10.1002/chem.201404013
12. [12]
  Y. Shao, Z.Y. Sun, Y. Wang, et al., ACS Appl. Mater. Interfaces 10 (2018) 9310-9314. doi: 10.1021/acsami.8b00312
13. [13]
  Z. Yin, H.G. Nguyen, S. Chowdhury, et al., Bioconjugate Chem. 23 (2012) 1694-1703. doi: 10.1021/bc300244a
14. [14]
  I. Companon, A. Guerreiro, V. Mangini, et al., J. Am. Chem. Soc. 141 (2019) 4063-4072. doi: 10.1021/jacs.8b13503
15. [15]
  J.J. Wu, W.H. Li, P.G. Chen, et al., Chem. Commun. 54 (2018) 9655-9658. doi: 10.1039/C8CC04860F
16. [16]
  X.G. Yin, X.Z. Chen, W.M. Sun, et al., Org. Lett. 19 (2017) 456-459. doi: 10.1021/acs.orglett.6b03591
17. [17]
  M. Glaffig, N. Stergiou, E. Schmitt, et al., ChemMedChem 12 (2017) 722-727. doi: 10.1002/cmdc.201700254
18. [18]
  F. Broecker, S. Gotze, J. Hudon, et al., J. Med. Chem. 61 (2018) 4918-4927. doi: 10.1021/acs.jmedchem.8b00312
19. [19]
  X. Wu, Z. Yin, C. McKay, et al., J. Am. Chem. Soc. 140 (2018) 16596-16609. doi: 10.1021/jacs.8b08473
20. [20]
  Z. Zhou, H. Lin, C. Li, et al., Chin. Chem. Lett. 29 (2018) 19-26. doi: 10.1016/j.cclet.2017.09.047
21. [21]
  H. Liu, Z. Jia, C. Yang, et al., Biomaterials 167 (2018) 32-43. doi: 10.1016/j.biomaterials.2018.03.014
22. [22]
  M. Skwarczynski, M. Zaman, C.N. Urbani, et al., Angew. Chem. Int. Ed. 49 (2010) 5742-5745. doi: 10.1002/anie.201002221
23. [23]
  S.S. Seregin, D.M. Appledorn, A.J. McBride, et al., Mol. Ther. 17 (2009) 685-696. doi: 10.1038/mt.2008.297
24. [24]
  S. Ingale, M.A. Wolfert, J. Gaekwad, et al., Nat. Chem. Biol. 3 (2007) 663-667. doi: 10.1038/nchembio.2007.25
25. [25]
  Z. Yin, X. Wu, K. Kaczanowska, et al., ACS Chem. Biol. 13 (2018) 1668-1676. doi: 10.1021/acschembio.8b00313
26. [26]
  T. Osada, M.A. Morse, H.K. Lyerly, et al., Int. Immunol. 17 (2005) 1143-1155. doi: 10.1093/intimm/dxh292
27. [27]
  K.L. Knutson, M.L. Disis, Cancer Immunol. Immunother. 54 (2005) 721-728. doi: 10.1007/s00262-004-0653-2
28. [28]
  Z. Yang, M. Xu, Z. Jia, et al., Biomaterials 134 (2017) 51-63. doi: 10.1016/j.biomaterials.2017.04.035
29. [29]
  H.Y. Qin, M.W. Sadelain, C. Hitchon, et al., J. Immunol. 150 (1993) 2072-2080.
30. [30]
  H. Huang, G.R. Ostroff, C.K. Lee, et al., Infect. Immun. 77 (2009) 1774-1781. doi: 10.1128/IAI.00086-09
31. [31]
  S. Leibundgut-Landmann, F. Osorio, G.D. Brown, et al., Blood 112 (2008) 4971-4980.
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