Citation: Lingzhi Chen, Xueqin Huang, Xueyi Zeng, Guiting Fang, Weijian Chen, Haibo Zhou, Xing Zhong, Huaihong Cai. Signal-on bimodal sensing glucose based on enzyme product-etching MnO₂ nanosheets for detachment of MoS₂ quantum dots[J]. Chinese Chemical Letters, ;2021, 32(6): 1967-1971. doi: 10.1016/j.cclet.2021.01.030 shu

Signal-on bimodal sensing glucose based on enzyme product-etching MnO₂ nanosheets for detachment of MoS₂ quantum dots

Lingzhi Chen ^{a, 1} ,
Xueqin Huang ^{b, 1} ,
Xueyi Zeng ^a ,
Guiting Fang ^c ,
Weijian Chen ^c ,
Haibo Zhou ^d ,
Xing Zhong ^{c, *,} ,
Huaihong Cai ^{a, *,}

a.
Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China
b.
State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau 000583, China
c.
Department of Ultrasonography, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China
d.
Institute of Pharmaceutical Analysis and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China

tzhxing@jnu.edu.cn

thhcai@jnu.edu.cn

Received Date: 24 August 2020
Revised Date: 11 January 2021
Accepted Date: 13 January 2021
Available Online: 20 January 2021

Figures(3)

The sensitive and rapid detection of blood glucose is very important for monitoring and managing diabetes. Herein, a fluorescent/magnetic bimodal sensing strategy is proposed for glucose detection using a multifunction-responsive nanocomposite (MoS₂ QDs-MnO₂ NS). MoS₂ QDs act as fluorescent probes, and MnO₂ nanosheets are used as both quenchers and recognizers in this sensing platform. In the presence of glucose-mediated enzyme product (H₂O₂), MnO₂ nanosheet is etched, thus releasing MoS₂ QDs and Mn²⁺ ions, which causes the significantly enhancement of fluorescent and magnetic signals. Furthermore, MoS₂ QDs-MnO₂ NS-based fluorescent test paper is constructed for H₂O₂ sensing with the naked eyes. Under optimal conditions, the dual linear ranges of 20-300 μmol/L and 40-250 μmol/L toward glucose detection are obtained for the fluorescent and magnetic mode, respectively. Furthermore, this bimodal assay exhibits good reproducibility and acceptable accuracy in glucose detection of clinical samples, demonstrating great versatility and flexibility of multifunctional probes in glucose detection.
- MoS₂ quantum dots,
- MnO₂ nanosheets,
- Bimodal sensing,
- Glucose detection,
- Fluorescent/magnetic enhancement
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Signal-on bimodal sensing glucose based on enzyme product-etching MnO2 nanosheets for detachment of MoS2 quantum dots

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Signal-on bimodal sensing glucose based on enzyme product-etching MnO₂ nanosheets for detachment of MoS₂ quantum dots