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Citation: Minghua Jiang, Zhenger Wu, Qilin Wu, Huimin Yin, Heng Guo, Siwen Yuan, Zhaoming Liu, Senhua Chen, Lan Liu. Amphichoterpenoids A–C, unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908[J]. Chinese Chemical Letters, ;2021, 32(6): 1893-1896. doi: 10.1016/j.cclet.2021.01.027 shu

Amphichoterpenoids A–C, unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908

Minghua Jiang ^{a, c} ,
Zhenger Wu ^a ,
Qilin Wu ^a ,
Huimin Yin ^a ,
Heng Guo ^a ,
Siwen Yuan ^a ,
Zhaoming Liu ^d ,
Senhua Chen ^{a, b, c, *,} ,
Lan Liu ^{a, b, c}

1.
School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China
2.
Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai), Zhuhai 519000, China
3.
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China
4.
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China

^*

chensenh@mail.sysu.edu.cn

Received Date: 12 November 2020
Revised Date: 5 January 2021
Accepted Date: 15 January 2021
Available Online: 20 January 2021

Figures(5)

Amphichoterpenoids A–C (1–3), unprecedented picoline-derived meroterpenoids possessing a pyrano[3, 2-c]pyridinyl-γ-pyranone scaffold, were characterized from the ascidian-derived fungus Amphichorda felina SYSU-MS7908. Their structures were elucidated by spectroscopic methods, X-ray diffraction and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway was proposed. The isolated compounds displayed moderate inhibitory activity against acetylcholinesterase with 50% inhibiting concentration (IC₅₀) values of 18.8–53.2 μmol/L.
- Fungal meroterpenoid,
- Picoline,
- Amphichorda felina,
- Encapsulated nanodroplet crystallization,
- Acetylcholinesterase
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