Citation: Huihui Zeng, Yujie Qi, Zheyu Zhang, Chuntai Liu, Weijun Peng, Yi Zhang. Nanomaterials toward the treatment of Alzheimer's disease: Recent advances and future trends[J]. Chinese Chemical Letters, ;2021, 32(6): 1857-1868. doi: 10.1016/j.cclet.2021.01.014 shu

Nanomaterials toward the treatment of Alzheimer's disease: Recent advances and future trends

Huihui Zeng ^a ,
Yujie Qi ^a ,
Zheyu Zhang ^b ,
Chuntai Liu ^c ,
Weijun Peng ^{b, *,} ,
Yi Zhang ^{a, *,}

a.
Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
b.
Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, China
c.
National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 450002, China

pengweijun87@csu.edu.cn

yzhangcsu@csu.edu.cn

Received Date: 22 November 2020
Revised Date: 6 January 2021
Accepted Date: 7 January 2021
Available Online: 12 January 2021

Figures(3)

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative condition and the most prevalent cause of dementia. This disease is characterized by progressive cognitive impairment. The prevalence of AD is currently affecting more than 35 million people and is rising worldwide. No efficient therapy is currently available due to low drug potency and a number of various obstacles to delivery. Recent nanotechnological advancements have the potential to offer promising therapeutic options. Progress on nanomaterials as well as their applications in biomedicine is receiving increasing attention, especially the advantages of nanomaterial-based drug delivery systems. The aim of this review is to comprehensively summarize the latest developments in nanomaterial-based strategies for AD treatment, including nanoparticles, liposomes and other options for the delivery of therapeutic compounds and scaffolds for cell delivery strategies. Future research directions are also proposed. We hope this review can provide important information to guide the future development of nanomaterials in AD treatment.
- Alzheimer's disease,
- Pathogenesis,
- Nanomaterials,
- β-Amyloid,
- Drug delivery
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