Citation: Lei Liu, Xin Du. Stellate porous silica based surface-enhanced Raman scattering system for traceable gene delivery[J]. Chinese Chemical Letters, ;2021, 32(6): 1942-1946. doi: 10.1016/j.cclet.2020.12.061 shu

Stellate porous silica based surface-enhanced Raman scattering system for traceable gene delivery

Lei Liu ^{a, b, c} ,
Xin Du ^{d, e, *,}

a.
Chemical Pharmaceutical Research Center, Tasly Academy, Tasly Holding Group Co., Ltd., Tianjin 300410, China
b.
Jiangsu Tasly Diyi Pharmaceutical Co., Ltd., Huaian 223003, China
c.
School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia
d.
Beijing Key Laboratory for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100083, China
e.
Suzhou Nachuangjia Environmental Technology Engineering Co., Ltd., Suzhou 215133, China

duxin@mail.ipc.ac.cn

Received Date: 5 October 2020
Revised Date: 30 December 2020
Accepted Date: 30 December 2020
Available Online: 5 January 2021

Figures(5)

Numerous nanocarriers have been currently developed for intracellular delivery. The potential cytotoxicity of these very small inorganic nanocarriers has raised great consideration. Thus, it becomes of utmost importance to conduct the intracellular trace of nanocarriers. Among many analytical techniques, surface enhanced Raman scattering (SERS) method is one of the current state-of-the-art techniques for cell visualization and trace. In this work, a novel stellate porous silica based gene delivery system has been designed for SERS trace purpose. A stellate porous silica nanoparticle modified with many small Au nanoparticles is designed to replace common metallic SERS tags. The results show that the designed system not only could deliver siRNA into cells for therapy, but also could realize SERS trace with high sensitivity and non-invasive features. The constructed delivery system has considerable potential to trace the dynamic gene delivery in living cells.
- Stellate porous silica,
- Au nanoparticles,
- Surface-enhanced Raman scattering,
- SERS trace,
- Gene delivery
1. [1]
  D. Peer, J. Karp, S. Hong, et al., Nat. Nanotechnol. 2 (2007) 751-760. doi: 10.1038/nnano.2007.387
2. [2]
  Y. Wang, P. Jarreau, Y. Xia, Nat. Mater. 10 (2011) 482-483. doi: 10.1038/nmat3060
3. [3]
  M. Davis, Z. Chen, D. Shin, et al., Nat. Rev. Drug Discovery 7 (2008) 771-782. doi: 10.1038/nrd2614
4. [4]
  Y. Wang, X. Du, Z. Liu, S. Shi, H. Lv, J. Mater. Chem. A: Mater. Energy Sustain. 7 (2019) 5111-5152. doi: 10.1039/C8TA09815H
5. [5]
  X. Du, S.Z. Qiao, Small 11 (2014) 392-413.
6. [6]
  H. Su, Q. Tian, C.A. Hurd Price, et al., Nano Today 31 (2020) 100834. doi: 10.1016/j.nantod.2019.100834
7. [7]
  L. Yin, Q. Tian, Y. Boyjoo, et al., Langmuir 36 (2020) 6984-6993. doi: 10.1021/acs.langmuir.9b03179
8. [8]
  J. Liu, T. Liu, J. Pan, S. Liu, G.Q. Lu, Annu. Rev. Chem. Biomol. Eng. 9 (2018) 389-411. doi: 10.1146/annurev-chembioeng-060817-084225
9. [9]
  Z. Wang, G. Liu, H. Zheng, X. Chen, Biotechnol. Adv. 32 (2014) 831-843. doi: 10.1016/j.biotechadv.2013.08.020
10. [10]
  Q. He, J. Shi, Adv. Mater. 26 (2014) 391-411. doi: 10.1002/adma.201303123
11. [11]
  Y. Gao, J. Xie, H. Chen, et al., Biotechnol. Adv. 32 (2014) 761-777. doi: 10.1016/j.biotechadv.2013.10.013
12. [12]
  C. Argyo, V. Weiss, C. Bräuchle, T. Bein, Chem. Mater. 26 (2014) 435-451. doi: 10.1021/cm402592t
13. [13]
  Z. Teng, X. Su, Y. Zheng, et al., Chem. Mater. 25 (2013) 98-105. doi: 10.1021/cm303338v
14. [14]
  X. Fang, X. Zhao, W. Fang, C. Chen, N. Zheng, Nanoscale 5 (2013) 2205-2218. doi: 10.1039/c3nr34006f
15. [15]
  M. Vendrell, K.K. Maiti, K. Dhaliwal, Y.T. Chang, Trends Biotechnol. 31 (2013) 249-257. doi: 10.1016/j.tibtech.2013.01.013
16. [16]
  B. Fahrenkrog, U. Aebi, Nat. Rev. Mol. Cell Biol. 4 (2003) 757-766. doi: 10.1038/nrm1230
17. [17]
  S. Keren, C. Zavaleta, Z. Cheng, et al., Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 5844-5849. doi: 10.1073/pnas.0710575105
18. [18]
  K.A. Stoerzinger, J.Y. Lin, T.W. Odom, Chem. Sci. 2 (2011) 1435-1439. doi: 10.1039/c1sc00125f
19. [19]
  S. Zong, Z. Wang, H. Chen, et al., IEEE Trans. Nanotechnol. 13 (2014) 55-60. doi: 10.1109/TNANO.2013.2287700
20. [20]
  S. Zong, Z. Wang, H. Chen, J. Yang, Y. Cui, Anal. Chem. 85 (2013) 2223-2230. doi: 10.1021/ac303028v
21. [21]
  D. Lin, T. Qin, Y. Wang, X. Sun, L. Chen, ACS Appl. Mater. Interfaces 6 (2014) 1320-1329. doi: 10.1021/am405396k
22. [22]
  L. Xiao, S. Harihar, D.R. Welch, A. Zhou, Anal. Chim. Acta 843 (2014) 73-82. doi: 10.1016/j.aca.2014.06.036
23. [23]
  Z. Wang, S. Zong, W. Li, et al., J. Am. Chem. Soc. 134 (2012) 2993-3000. doi: 10.1021/ja208154m
24. [24]
  J. Xie, Q. Zhang, J.Y. Lee, D.I.C. Wang, ACS Nano 2 (2008) 2473-2480. doi: 10.1021/nn800442q
25. [25]
  J. Fang, S. Du, S. Lebedkin, et al., Nano Lett. 10 (2010) 5006-5013. doi: 10.1021/nl103161q
26. [26]
  Z. Wang, J. Zhang, J.M. Ekman, P.J.A. Kenis, Y. Lu, Nano Lett. 10 (2010) 1886-1891. doi: 10.1021/nl100675p
27. [27]
  Q. Li, Y. Jiang, R. Han, et al., Small 9 (2013) 927-932. doi: 10.1002/smll.201201065
28. [28]
  Y. Lai, L. Dong, R. Liu, et al., Chin. Chem. Lett. 31 (2020) 2437-2441. doi: 10.1016/j.cclet.2020.04.050
29. [29]
  A.M. Fales, H. Yuan, T. Vo-Dinh, Langmuir 27 (2011) 12186-12190. doi: 10.1021/la202602q
30. [30]
  A.M. Fales, H. Yuan, T. Vo-Dinh, J. Mol. Pharm. Org. Process Res. 10 (2013) 2291-2298.
31. [31]
  H. Yuan, A.M. Fales, C.G. Khoury, J. Liu, T. VoDinh, J. Raman Spectrosc. 44 (2013) 234-239. doi: 10.1002/jrs.4172
32. [32]
  J. Yang, L. Xia, Z. Lin, et al., Chin. Chem. Lett. 30 (2019) 638-642. doi: 10.1016/j.cclet.2018.08.004
33. [33]
  L. Xiong, X. Du, B. Shi, et al., J. Mater. Chem. B: Mater. Biol. Med. 3 (2015) 1712-1721. doi: 10.1039/C4TB01601G
34. [34]
  K. Zhang, L.L. Xu, J.G. Jiang, et al., J. Am. Chem. Soc. 135 (2013) 2427-2430. doi: 10.1021/ja3116873
35. [35]
  X. Du, J. He, Nanoscale 4 (2012) 852-859. doi: 10.1039/C1NR11504A
36. [36]
  L. Wei, B. Jin, S. Dai, J. Phys. Chem. C 116 (2012) 17174-17181. doi: 10.1021/jp302651x
37. [37]
  A. Michota, J. Bukowska, J. Raman Spectrosc. 34 (2003) 21-25. doi: 10.1002/jrs.928
38. [38]
  P.H.C. Camargo, L. Au, M. Rycenga, W. Li, Y. Xia, Chem. Phys. Lett. 484 (2010) 304-308. doi: 10.1016/j.cplett.2009.12.002
39. [39]
  W. Ngamcherdtrakul, J. Morry, S. Gu, et al., Adv. Funct. Mater. 25 (2015) 2646-2659. doi: 10.1002/adfm.201404629
40. [40]
  J. Morry, W. Ngamcherdtrakul, S. Gu, et al., Biomaterials 66 (2015) 41-52. doi: 10.1016/j.biomaterials.2015.07.005
41. [41]
  M.Y. HanafiBojd, L. Ansar, B. Malaekeh-Nikouei, Ther. Deliv. 7 (2016) 649-655. doi: 10.4155/tde-2016-0045
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