Citation: Dandan Bu, Yuying Wang, Na Wu, Wei Feng, Donghui Wei, Zhanxian Li, Mingming Yu. A mitochondrial-targeted ratiometric probe for detecting intracellular H₂S with high photostability[J]. Chinese Chemical Letters, ;2021, 32(5): 1799-1802. doi: 10.1016/j.cclet.2020.12.044 shu

A mitochondrial-targeted ratiometric probe for detecting intracellular H₂S with high photostability

Dandan Bu ^{a, 1} ,
Yuying Wang ^{a, 1} ,
Na Wu ^b ,
Wei Feng ^b ,
Donghui Wei ^a ,
Zhanxian Li ^{a, *,} ,
Mingming Yu ^{a, *,}

a.
Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China
b.
Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Institutes of Biomedical Sciences & Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China

Received Date: 27 August 2020
Revised Date: 22 December 2020
Accepted Date: 23 December 2020
Available Online: 29 December 2020

Figures(6)

Based on 4-bromo-1, 8-naphthalic anhydride, one novel ratiometric fluorescence H₂S-probe (IDNA) was designed and synthesized. Further studies indicate that IDNA can sensitively recognize H₂S (detection limit of 7 μmol/L) with good selectivity and anti-interference ability. In addition, IDNA has satisfactory photostability in HeLa cells, ability of mitochondrial co-localization, and can be utilized in fluorescence imaging of H₂S.
- Ratiometric,
- H₂S,
- Mitochondrial localization,
- Fluorescent probe,
- Biological imaging
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通讯作者: 陈斌, bchen63@163.com

A mitochondrial-targeted ratiometric probe for detecting intracellular H₂S with high photostability