Citation: Haoyuan Lv, Shuai Ma, Zhenbo Wang, Xiaoting Ji, Shaoping Lv, Caifeng Ding. Glutathione-triggered non-template synthesized porous carbon nanospheres serve as low toxicity targeted delivery system for cancer multi-therapy[J]. Chinese Chemical Letters, ;2021, 32(5): 1765-1769. doi: 10.1016/j.cclet.2020.11.058 shu

Glutathione-triggered non-template synthesized porous carbon nanospheres serve as low toxicity targeted delivery system for cancer multi-therapy

Haoyuan Lv ^a ,
Shuai Ma ^a ,
Zhenbo Wang ^a ,
Xiaoting Ji ^a ,
Shaoping Lv ^b ,
Caifeng Ding ^{a, b, *,}

a.
Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
b.
Qingdao Central Hospital, Qingdao 266042, China

dingcaifeng2003@163.com

Received Date: 3 October 2020
Revised Date: 23 November 2020
Available Online: 3 December 2020

Figures(5)

Nanomaterial based drug delivery system have received great attention in clinical application due to their high therapeutic efficacy and lower side effects than classical method, multi-functional nanomaterial also have shown the excellent performance at cancer theranostic and durg tracking in vivo and in vitro. However, most of these works are influenced by the bio-toxicity of applied nanomaterials, which could influence the diagnostic results and treatment effect. Therefore, we have prepared a high biocompatibility porous carbon nanospheres (PCNs) based nano-system (PCN-siRNA-DOX-FA) for targeted drug delivery and theranostic. The surface modifications have increased dispersion and stability of the PCNs, and folic acid (FA) had enhanced the active target ability for FA receptor positive cell lines. Moreover, through the siRNA structure and doxorubicin (DOX) loading, biological and chemical combined multi-therapy was achieved in cancerous cells. This constructed nano-system could positively improve the biotoxicity problem of nanomaterial and provide a potential platform for clinical cancer theranostic applications.
- Cell imaging analysis,
- Drug delivery,
- Biothiol sensing,
- Low biotoxicity,
- Porous carbon
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