Citation: Die Jia, Xianbin Ma, Yi Lu, Xinyi Li, Shengxin Hou, Yuan Gao, Peng Xue, Yuejun Kang, Zhigang Xu. ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer[J]. Chinese Chemical Letters, ;2021, 32(1): 162-167. doi: 10.1016/j.cclet.2020.11.052 shu

ROS-responsive cyclodextrin nanoplatform for combined photodynamic therapy and chemotherapy of cancer

Die Jia ^{a, b, 1} ,
Xianbin Ma ^{a, b, 1} ,
Yi Lu ^{a, b} ,
Xinyi Li ^{a, b} ,
Shengxin Hou ^{a, b} ,
Yuan Gao ^{a, b} ,
Peng Xue ^{a, b} ,
Yuejun Kang ^{a, b} ,
Zhigang Xu ^{a, b, *,}

a.
State Key Laboratory of Silkworm Genome Biology, School of Materials and Energy, Southwest University, Chongqing 400715, China
b.
Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China

zgxu@swu.edu.cn

Received Date: 14 September 2020
Revised Date: 25 November 2020
Accepted Date: 25 November 2020
Available Online: 1 December 2020

Figures(4)

Cyclodextrin (CD) has special spatial structure and well biological safety, so it has been widely used for constructing CD-based nanoplatforms. Through functionalization, cyclodextrin can form various stimulus-response nanoplatforms, such as pH, temperature, redox, light and magnetic fields. In this study, we designed a highly sensitive reactive oxygen species (ROS)-responsive polymer PCP which encapsulated doxorubicin (DOX) and purpurin 18 (P18) to achieve the synergy of photodynamic and chemotherapy. The high content of reactive oxygen species(ROS) in the tumor microenvironment(TME) triggers the cleavage of the borate bond of MPEG-CD-PHB(PCP), thereby promoting the release of drugs.When irradiated with near-infrared laser, the photosensitizer P18 released by polymer micelles can produce reactive oxygen species to promote cell apoptosis. Compared with monotherapy, a series of experiments confirmed that our micelles had enhanced anti-cancer activity. This work was beneficial to the design of ROS-responsive materials and provides an effective strategy for the application of collaborative anti-tumor therapy.
- Chemotherapy,
- Photodynamic therapy,
- Synergistic therapy,
- Cyclodextrins,
- ROS-responsive
1. [1]
  A.N. Zelikin, C. Ehrhardt, A.M. Healy, Nat. Chem. 8(2016) 997-1007. doi: 10.1038/nchem.2629
2. [2]
  G. Yu, X. Chen, Theranostics 9(2019) 3041-3074. doi: 10.7150/thno.31653
3. [3]
  L. Yu, Y. Chen, H.R. Chen, Chin. Chem. Lett. 28(2017) 1841-1850. doi: 10.1016/j.cclet.2017.05.023
4. [4]
  Z. Xu, X. Ma, Y.E. Gao, et al., Mater. Chem. Front. 1(2017) 1257-1272. doi: 10.1039/C7QM00153C
5. [5]
  T. Miao, J. Wang, Y. Zeng, et al., Adv. Sci. 5(2018) 1700513. doi: 10.1002/advs.201700513
6. [6]
  J. Du, H. Li, J. Wang, Acc. Chem. Res. 51(2018) 2848-2856. doi: 10.1021/acs.accounts.8b00195
7. [7]
  Y. Zhao, J. Peng, J. Li, L. Huang, et al., Nano Lett. 17(2017) 4096-4100. doi: 10.1021/acs.nanolett.7b00828
8. [8]
  D. Chen, Z. Zhong, Q. Ma, et al., ACS Appl. Mater. Interfaces 12(2020) 26914-26915. doi: 10.1021/acsami.0c05021
9. [9]
  J. Liu, Y. Huang, A. Kumar, et al., Biotechnol. Adv. 32(2014) 693-710. doi: 10.1016/j.biotechadv.2013.11.009
10. [10]
  L.F. Han, L.J. Hu, F.L. Liu, Asian J. Pharm. Sci. 14(2019) 531-542. doi: 10.1016/j.ajps.2018.08.009
11. [11]
  M. Upreti, A. Jyoti, P. Sethi, Mol. Cancer Res. 2(2013) 309-319. doi: 10.3978/j.issn.2218-676X.2013.08.11
12. [12]
  E.S. Nakasone, H.A. Askautrud, T. Kees, et al., Cancer Cell 21(2012) 488-503. doi: 10.1016/j.ccr.2012.02.017
13. [13]
  P. Liang, X. Huang, Y. Wang, et al., ACS Nano 12(2018) 11446-11457. doi: 10.1021/acsnano.8b06478
14. [14]
  K.L. Ding, C.X. Zheng, L.L. Sun, et al., Chin. Chem. Lett. 31(2020) 1168-1172. doi: 10.1016/j.cclet.2019.10.040
15. [15]
  M. Kanamala, W.R. Wilson, M. Yang, Biomaterials 85(2016) 152-167. doi: 10.1016/j.biomaterials.2016.01.061
16. [16]
  Q. Hu, W. Sun, Y. Lu, et al., Nano Lett. 16(2016) 1118-1126. doi: 10.1021/acs.nanolett.5b04343
17. [17]
  S. Bai, L.L. Yang, Y.J. Wang, et al., Small 16(2020) 2000214. doi: 10.1002/smll.202000214
18. [18]
  X.X. Shi, Y. Zhang, Y. Tian, et al., Small Methods (2020) 2000416.
19. [19]
  S.T. Gao, G.S. Tang, D.W. Hua, J. Mater. Chem. B 7(2019) 709-729. doi: 10.1039/C8TB02491J
20. [20]
  E.K. Lim, T. Kim, S. Paik, et al., Chem. Rev. 115(2015) 327-394. doi: 10.1021/cr300213b
21. [21]
  W. Fan, B. Yung, P. Huang, et al., Chem. Rev. 117(2017) 13566-13638. doi: 10.1021/acs.chemrev.7b00258
22. [22]
  D. Chen, Q. Yu, X. Huang, et al., Small 16(2020) 2001059. doi: 10.1002/smll.202001059
23. [23]
  X. Song, Y. Wen, J.L. Zhu, et al., Biomacromolecules 17(2016) 3957-3963. doi: 10.1021/acs.biomac.6b01344
24. [24]
  L. Lin, H. Gong, R. Li, Adv. Sci. 7(2020) 1903138. doi: 10.1002/advs.201903138
25. [25]
  L. Wei, Y. Zhao, X. Hu, et al., ACS Cent. Sci. 6(2020) 404-412. doi: 10.1021/acscentsci.9b01174
26. [26]
  B. Hou, L. Zhou, H. Wang, et al., Adv. Mater. 32(2020) 1907210. doi: 10.1002/adma.201907210
27. [27]
  J. Lee, E.T. Oh, H. Yoon, et al., Nanoscale 9(2017) 6901-6909. doi: 10.1039/C7NR00808B
28. [28]
  Y. Yang, Y.M. Zhang, Y. Chen, et al., Sci. Rep. 6(2016) 19212. doi: 10.1038/srep19212
29. [29]
  Q. Zhang, F. Zhang, Y. Chen, et al., Chem. Mater. 29(2017) 8221-8238. doi: 10.1021/acs.chemmater.7b02412
30. [30]
  T. Zhang, J. Yao, J. Tian, et al., Chin. Chem. Lett. 31(2020) 1129-1132. doi: 10.1016/j.cclet.2019.07.010
31. [31]
  F. Bahrami, M.J. Abdekhodaie, F. Behroozi, et al., Chin. Chem. Lett. 57(2020) 101510. doi: 10.1016/j.jddst.2020.101510
32. [32]
  P.F. Zhang, J.Q. Wang, H. Chen, et al., J. Am. Chem. Soc. 140(2018) 14980-14989. doi: 10.1021/jacs.8b09396
33. [33]
  S.J. Leung, M. Romanowski, Adv. Mater. 24(2012) 6380-6383. doi: 10.1002/adma.201202180
34. [34]
  M. Wang, S. Sun, C.I. Neufeld, Angew. Chem. 126(2014) 13662-13666. doi: 10.1002/ange.201407234
35. [35]
  Z.Y. Cao, Y.C. Ma, C.Y. Sun, Chem. Mater. 30(2018) 517-525. doi: 10.1021/acs.chemmater.7b04751
36. [36]
  Y.N. Antonenko, A.V. Avetisyan, L.E. Bakeeva, et al., Biochemistry 73(2008) 1273-1287. doi: 10.1016/j.bbabio.2014.07.006
37. [37]
  M. Dong, X. Xiao, Z. Su, et al., Small 15(2019) 1900212. doi: 10.1002/smll.201900212
38. [38]
  Y. Cheng, A.C. Samia, J.D. Meyers, J. Am. Chem. Soc. 130(2008) 10643-10647. doi: 10.1021/ja801631c
39. [39]
  X. Liu, J. Xiang, D. Zhu, et al., Adv. Mater. 28(2016) 1743-1752. doi: 10.1002/adma.201504288
40. [40]
  Q. Wei, Y. Chen, X. Ma, et al., Adv. Funct. Mater. 28(2018) 1704634. doi: 10.1002/adfm.201704634
1. [1]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
2. [2]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
3. [3]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
4. [4]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
5. [5]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
6. [6]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
7. [7]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
8. [8]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
9. [9]
  Wenkai Liu , Yanxian Hou , Weijian Liu , Ran Wang , Shan He , Xiang Xia , Chengyuan Lv , Hua Gu , Qichao Yao , Qingze Pan , Zehou Su , Danhong Zhou , Wen Sun , Jiangli Fan , Xiaojun Peng . Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process. Chinese Chemical Letters, 2024, 35(12): 109631-. doi: 10.1016/j.cclet.2024.109631
10. [10]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
11. [11]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
12. [12]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
13. [13]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
14. [14]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
15. [15]
  Di An , Mingdong She , Ziyang Zhang , Ting Zhang , Miaomiao Xu , Jinjun Shao , Qian Shen , Xuna Tang . Light-responsive nanomaterials for biofilm removal in root canal treatment. Chinese Chemical Letters, 2025, 36(2): 109841-. doi: 10.1016/j.cclet.2024.109841
16. [16]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
17. [17]
  Qihang Wu , Hui Wen , Wenhai Lin , Tingting Sun , Zhigang Xie . Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment. Chinese Chemical Letters, 2024, 35(12): 109692-. doi: 10.1016/j.cclet.2024.109692
18. [18]
  Linjie Ju , Zhongxi Huang , Qian Shen , Chan Fu , Shuanghe Li , Wenjie Duan , Chenfeng Xu , Weizhen An , Zhiqiang Zhai , Jifu Wei , Changmin Yu , Guoren Zhou . Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy. Chinese Chemical Letters, 2024, 35(10): 109450-. doi: 10.1016/j.cclet.2023.109450
19. [19]
  Chuyu Huang , Zhishan Liu , Linping Zhao , Zuxiao Chen , Rongrong Zheng , Xiaona Rao , Yuxuan Wei , Xin Chen , Shiying Li . Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination. Chinese Chemical Letters, 2024, 35(12): 109696-. doi: 10.1016/j.cclet.2024.109696
20. [20]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018

Get Citation

PDF

XML

Metrics

PDF Downloads(21)
Abstract views(1204)
HTML views(161)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142