Citation: Chuanfeng Liu, Zhixin Li, Hai Yu, Naibin Cui, Xiaoyu Liao, Haibin Zhang, Zhengning Shu, Peng Yang. Host-guest co-assembly triggered turn-on and ratiometric sensing of berberine and its detoxicating[J]. Chinese Chemical Letters, ;2021, 32(4): 1385-1389. doi: 10.1016/j.cclet.2020.10.048 shu

Host-guest co-assembly triggered turn-on and ratiometric sensing of berberine and its detoxicating

Chuanfeng Liu ^a ,
Zhixin Li ^a ,
Hai Yu ^a ,
Naibin Cui ^a ,
Xiaoyu Liao ^b ,
Haibin Zhang ^a ,
Zhengning Shu ^a ,
Peng Yang ^{a, *,}

a.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

yangpeng@syphu.edu.cn

Received Date: 4 August 2020
Revised Date: 16 October 2020
Accepted Date: 30 October 2020
Available Online: 2 November 2020

Figures(9)

Fluorescent sensing for specific detection of berberine is an important issue in view of its potential jeopardization to food safety and human health, but remains less investigated. To the best of our knowledge, there is no fluorescence turn-on and ratiometric sensors available for specific detection of berberine. In this study, calix[4]carbazole (3) has been synthesized and its property of recognizing berberine has been evaluated by UV–vis, fluorescence, NMR, DLS and TEM techniques. The results show that 3 selectively recognizes berberine among the tested drugs and detects it with turn-on and ratiometric fluorescence due to their co-assembly nature. Moreover, 3 is not only low toxic and can reduce toxicity of berberine to human normal liver L02 cell, but also can release berberine to tumor HepG2 cells at acid micro-environment. It therefore holds a great potential for further exploration
- Recognition,
- Macrocycle,
- Host-guest,
- Sensor,
- Carbazole
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