Citation: Fan Liao, Hanxuan Wang, Yuankun Dao, Kai Yuan, Jiazhen Lu, Jie Shi, Ying Han, Suwei Dong, Lin Lu. Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine[J]. Chinese Chemical Letters, ;2021, 32(4): 1575-1579. doi: 10.1016/j.cclet.2020.10.038 shu

Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine

Fan Liao ^a ,
Hanxuan Wang ^c ,
Yuankun Dao ^c ,
Kai Yuan ^a ,
Jiazhen Lu ^{d, e} ,
Jie Shi ^b ,
Ying Han ^{b, *,} ,
Suwei Dong ^{c, *,} ,
Lin Lu ^{a, d, **,}

a.
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
b.
National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China
c.
State Key Laboratory of Natural and Biomimetic Drugs, and Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
d.
Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Academy for Advanced Interdisciplinary Studies Peking University, Beijing 100871, China
e.
School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

^**

yinghan@bjmu.edu.cn

dongsw@pku.edu.cn

linlu@bjmu.edu.cn

Received Date: 21 August 2020
Revised Date: 9 October 2020
Accepted Date: 23 October 2020
Available Online: 24 October 2020

Figures(6)

We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine (METH) vaccine that contains three components: Toll-like receptor 2 ligand, Th2 epitope, and METH hapten. The immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH molecule. Behavioral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor sensitization. These results demonstrate that the lipopeptide-based vaccine has invoked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH.
- METH vaccine,
- Carrier protein-free,
- Fully synthesis,
- Lipopeptide,
- Behavioral model
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