Citation: Zifen Li, Yanxue Yang, Chuan Peng, Hang Liu, Rui Yang, Yi Zheng, Lulu Cai, Hong Tan, Qiang Fu, Mingming Ding. Drug-induced hierarchical self-assembly of poly(amino acid) for efficient intracellular drug delivery[J]. Chinese Chemical Letters, ;2021, 32(4): 1563-1566. doi: 10.1016/j.cclet.2020.10.016 shu

Drug-induced hierarchical self-assembly of poly(amino acid) for efficient intracellular drug delivery

Zifen Li ^a ,
Yanxue Yang ^{a, b} ,
Chuan Peng ^a ,
Hang Liu ^a ,
Rui Yang ^a ,
Yi Zheng ^a ,
Lulu Cai ^{b, *,} ,
Hong Tan ^a ,
Qiang Fu ^a ,
Mingming Ding ^{a, *,}

a.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
b.
Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China

cailulu@med.uestc.edu.cn

dmmshx@scu.edu.cn

Received Date: 11 September 2020
Revised Date: 12 October 2020
Accepted Date: 13 October 2020
Available Online: 15 October 2020

Figures(4)

As a potent anticancer drug, gambogic acid (GA) suffers from its poor water solubility and low chemical stability and shows a limited clinical outcome. To address this problem, we report here a simple and effective strategy to immobilize and deliver GA using a reducible diblock poly(amino acid) as a model. The electrostatic interaction between GA and polymer enables a high drug loading content up to 53.6 %. Moreover, the drug complexation induces a micelle-to-vesicle transformation, combined with a conformation transition from random coil to α-helix. The hierarchically assembled drug nanocomplexes can serve as a smart carrier for efficient cell internalization and triggered release of multiple drugs under intracellular acidic and reductive conditions, resulting in a synergistic antitumor efficacy in vitro. This work provides a new insight into the drug-carrier interaction and a facile nanoplatform for drug delivery applications.
- Poly(amino acid)s,
- Electrostatic complexation,
- Gambogic acid,
- Hierarchical self-assembly,
- Secondary conformation
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